Objective. 2009 H1N1 virus is a new virus that was firstly detected in April 2009. This virus spreads from human to human and causes a worldwide disease. This paper aimed to review the clinical and epidemiological properties of patients with 2009 H1N1 influenza who were hospitalized and monitored at Eskisehir Osmangazi University Faculty of Medicine Hospital. Setting. A 1000-bed teaching hospital in Eskisehir, Turkey. Patients-Methods. Between 05 November 2009–01 February 2010, 106 patients with 2009 H1N1 influenza, who were hospitalized, were prospectively evaluated. Results. Out of 106 patients who were hospitalized and monitored, 99 (93.4%) had fever, 86 (81.1%) had cough, 48 (45.3%) had shortness of breath, 47 (44.3%) had sore throat, 38 (35.8%) had body pain, 30 (28.3%) had rhinorrhea, 17 (16%) had vomiting, 15 (14.2%) had headache, and 14 (13.2%) had diarrhea. When the patients were examined in terms of risk factors for severe disease, 83 (78.3%) patients had at least one risk factor. During clinical monitoring, pneumonia was the most frequent complication with a rate of 66%. While 47.2% of the patients were monitored in intensive care unit, 34% of them required mechanical ventilation support. Conclusion. Patients with 2009 H1N1 influenza, who were hospitalized and monitored, should be carefully monitored and treated. 1. Introduction 2009 H1N1 virus is a new virus that was firstly detected in April 2009. This virus spreads from human to human and causes a worldwide disease. In 2009 H1N1 influenza, the symptoms include fever, tremor, rhinorrhea, cough, chest pain, body pain, headache, tiredness, diarrhea, and vomiting [1]. For 2009 H1N1 influenza infection, chronic lung disease, immunosuppression, and pregnancy were detected as risk factors for severe disease [2–4]. Throughout the pandemic period, a majority of the patients, who were below 2 years, above 65 years, and had underlying disease, were hospitalized and monitored [5, 6]. This study aimed to review the clinical and epidemiological properties of patients with 2009 H1N1 influenza who were hospitalized and monitored at Eskisehir Osmangazi University, Faculty of Medicine Hospital. 2. Materials and Methods Between 05 November 2009–01 February 2010, 106 patients with 2009 H1N1 influenza, who were hospitalized and monitored at Eskisehir Osmangazi University, School of Medicine Hospital, were prospectively evaluated. The patients’ demographics, complaints related to admission to hospital, duration of disease, physical examination findings, laboratory and radiological findings, name of the clinic
References
[1]
Centers for Disease Control and Prevention, “2009 H1N1 Flu (“Swine Flu”) and You Centers for Disease Control and Prevention” http://www.cdc.gov/h1n1flu/qa.htm.
[2]
F. S. Dawood, S. Jain, L. Finelli et al., “Emergence of a novel swine-origin influenza A (H1N1) virus in humans,” The New England Journal of Medicine, vol. 360, no. 25, pp. 2605–2615, 2009.
[3]
Centers for Disease Control and Prevention, “Hospitalized patients with novel influenza a (H1N1) virus infection—California,” Morbidity and Mortality Weekly Report, vol. 58, no. 19, pp. 536–541, 2009.
[4]
A. E. Fiore, D. K. Shay, K. Broder et al., “Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009,” Morbidity and Mortality Weekly Report, vol. 58, no. 8, pp. 1–52, 2009.
[5]
A. E. Fiore, D. K. Shay, K. Broder et al., “Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008,” Morbidity and Mortality Weekly Report, vol. 57, no. 7, pp. 1–60, 2008.
[6]
W. W. Thompson, D. K. Shay, E. Weintraub et al., “Influenza-associated hospitalizations in the United States,” JAMA, vol. 292, no. 11, pp. 1333–1340, 2004.
[7]
Centers for Disease Control and Prevention, “2009 pandemic influenza a (H1N1) virus infections—Chicago, illinois,” Morbidity and Mortality Weekly Report, vol. 58, no. 33, pp. 913–918, 2009.
[8]
A. Nougairède, L. Ninove, C. Zandotti et al., “Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009,” PLoS One, vol. 5, no. 2, Article ID e9214, 2010.
[9]
F. Tulloch, R. Correa, G. Guerrero et al., “Profile of the first cases hospitalized due to influenza A (H1N1) 2009 in Panama City, Panama, May-June 2009,” Journal of Infection in Developing Countries, vol. 3, no. 11, pp. 811–816, 2009.
[10]
J. K. Louie, M. Acosta, K. Winter et al., “Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California,” JAMA, vol. 302, no. 17, pp. 1896–1902, 2009.
[11]
S. Jain, L. Kamimoto, A. M. Bramley et al., “Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009,” The New England Journal of Medicine, vol. 361, no. 20, pp. 1935–1944, 2009.
[12]
D. J. Jamieson, M. A. Honein, S. A. Rasmussen et al., “H1N1 2009 influenza virus infection during pregnancy in the USA,” The Lancet, vol. 374, no. 9688, pp. 451–458, 2009.
[13]
L. Dodds, S. A. McNeil, D. B. Fell et al., “Impact of influenza exposure on rates of hospital admissions and physician visits because of respiratory illness among pregnant women,” CMAJ, vol. 176, no. 4, pp. 463–468, 2007.
[14]
K. M. Neuzil, G. W. Reed, E. F. Mitchel, L. Simonsen, and M. R. Griffin, “Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women,” American Journal of Epidemiology, vol. 148, no. 11, pp. 1094–1102, 1998.
[15]
D. W. Freeman and A. Barno, “Deaths from Asian influenza associated with pregnancy,” American Journal of Obstetrics and Gynecology, vol. 78, pp. 1172–1175, 1959.
[16]
L. Lindsay, L. A. Jackson, D. A. Savitz et al., “Community influenza activity and risk of acute influenza-like illness episodes among healthy unvaccinated pregnant and postpartum women,” American Journal of Epidemiology, vol. 163, no. 9, pp. 838–848, 2006.
[17]
S. A. Rasmussen, D. J. Jamieson, K. MacFarlane, J. D. Cragan, J. Williams, and Z. Henderson, “Pandemic influenza and pregnant women: summary of a meeting of experts,” American Journal of Public Health, vol. 99, no. 2, pp. S248–S254, 2009.
[18]
Centers for Disease Control and Prevention, “Hospitalized patients with novel influenza A (H1N1) virus infection—California,” Morbidity and Mortality Weekly Report, vol. 58, pp. 536–541, 2009.
[19]
R. Riquelme, M. Riquelme, M. L. Rioseco, et al., “Characteristics of hospitalised patients with 2009 H1N1 influenza in Chile,” European Respiratory Journal, vol. 36, no. 4, pp. 864–869, 2010.
