OALib Journal期刊
ISSN: 2333-9721
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整合素αvβ6和junb在口腔鳞癌组织中的表达及其临床意义
Keywords: 整合素αvβ6,口腔鳞癌,junb,免疫组织化学
Abstract:
?目的:探讨整合素αvβ6、junb在口腔鳞癌组织中的表达及其临床意义。方法:采用免疫组化方法检测120例口腔鳞癌及15例口腔正常黏膜组织中整合素αvβ6和junb的表达情况,并分析两者表达与口腔鳞癌患者临床病理指标及预后的关系。结果:整合素αvβ6表达于口腔鳞癌组织的细胞质和胞膜,而junb定位在口腔鳞癌组织和口腔正常黏膜组织的细胞核内。整合素αvβ6、junb在口腔鳞癌组织中的表达强度显著高于口腔正常黏膜组织(p<0.01)。整合素αvβ6在口腔鳞癌组织中的表达与浸润深度(t分期)、组织分化程度、是否有淋巴结转移(n分期)密切相关(p<0.05),而junb在口腔鳞癌组织中的表达与浸润深度、是否有淋巴结转移密切相关(p<0.05)。单因素生存分析表明,整合素αvβ6高表达患者的预后较低表达的患者差(p=0.021)。cox回归多因素分析表明是否有淋巴结转移是影响患者预后的独立危险因素(p<0.05)。结论:整合素αvβ6和junb在口腔鳞癌组织中表达增加,并与口腔鳞癌的浸润、转移密切相关;整合素αvβ6表达可作为判断口腔鳞癌患者预后判断的指标。
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