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OALib Journal期刊
ISSN: 2333-9721
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腺样囊性癌细胞雪旺细胞化在嗜神经侵袭中的作用
Keywords: 腺样囊性癌,嗜神经侵袭,雪旺细胞,s100a4,神经胶质原纤维配性蛋白,髓鞘碱性蛋白
Abstract:
？腺样囊性癌是否发生嗜神经侵袭(pni)是影响患者预后和生存质量的重要因素,发生pni将严重影响患者的5年生存率。目前腺样囊性癌发生pni的具体机制仍未明了,不过近年来许多研究发现,雪旺细胞的标志物s100a4蛋白、神经胶质原纤维配性蛋白(gfap)、髓鞘碱性蛋白(mbp)等在腺样囊性癌细胞多呈阳性表达,而在正常组织中无表达,因此肿瘤细胞的雪旺细胞化可能在pni发展中具有重要意义。本文综述了多种腺样囊性癌中肿瘤细胞表达雪旺细胞标志物s100a4、gfap、mbp及其在pni进程中的可能机制,以期为肿瘤防治提供新的研究思路。
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