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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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toll样受体2基因多态性与胃癌及eb病毒相关胃癌易感性的关系
Keywords: 胃癌,eb病毒,toll样受体,单核苷酸多态性
Abstract:
？目的:探讨toll样受体2(tlr2)rs3804099和rs3804100基因多态性与胃癌和eb病毒相关胃癌(ebvagc)易感性的关系。方法:选用185例ebv阴性胃癌(ebvngc)组织、41例ebvagc组织以及100位健康人群外周血标本作为研究对象,采用pcr结合限制性片段长度多态性(rflp)技术检测tlr2rs3804099与rs3804100的基因多态性。结果:tlr2rs3804099基因型和等位基因频率在胃癌组与健康对照组间的差异均有统计学意义(χ2=5.617,p=0.018;χ2=6.467,p=0.011),胃癌组c等位基因频率及c等位基因携带者频率均明显高于健康对照组(χ2=6.467,p=0.011;χ2=4.444,p=0.035),且与野生tt型相比,cc基因型可增加胃癌的发病风险(or=3.554,95%ci=1.179~10.715)。tlr2rs3804100位点的各基因型频率、c等位基因及c等位基因携带者的频率在胃癌组和健康对照组之间差异无统计学意义(p>0.05)。tlr2rs3804099与rs3804100位点的各基因型频率、c等位基因频率及c等位基因携带者频率在ebvagc和ebvngc两组间的差异均无统计学意义(p>0.05)。结论:tlr2rs3804099基因多态性可能与胃癌发病风险有关,c等位基因可能为胃癌的危险因子,携带c等位基因可能增加胃癌的发病风险。tlr2rs3804099与rs3804100基因的多态性与ebvagc的易感性无明显相关性。
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