The construction and performance characteristics of a novel (diphenhydramine) DPH CC-sensor
based on DZCE were reported in this work. The CC-membrane was prepared by incorporating of
(diazacrown ether) DZCE and/or (tetraflorophenyl borate) TFPB into a plasticized poly(vinyl
chloride) membrane. The CC-sensor revealed a Nernstian behavior over a DPH-concentration
range (9.1 × 10-3 - 6.3 × 10-7 mol ·L-1), and relatively low detection limit (1 × 10-7 mol ·L-1). The potentiometric
response was independent on the pH of the solution in the range of 7 - 10. The
DPH-CC showed a very short response time (<5 s). It showed good selectivity towards different cations
and pharmaceutical compounds. The relative selectivity coefficient was applied for evaluation
of the selectivity properties of the DPH-CC. The DPH-CC was used successfully for determination
of DPH in its samples. The found recovery range was 95% - 98.5%, and the standard deviation
value ranged between 0.13 - 0.42. The DPH-CC facilitates the analysis of DPH directly without pretreatment
and it can be built-in as a detector in chromatographic apparatus. It can be used as a
tool for on-line monitoring of the drug levels.
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[7]
Gomez, M.R., Sombra, L., Olsina, R.A., Martínez, L.D. and Silva, M.F. (2005) Development and Validation of a Capillary Electrophoresis Method for the Determination of Codeine, Diphenhydramine, Ephedrine and Noscapine in Pharmaceuticals. Il Farmaco, 60, 85-90. http://dx.doi.org/10.1016/j.farmac.2004.11.002
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Barbas, C., Garcia, A., Saavedra, L. and Castro, M. (2000) Optimization and Validation of a Method for the Determination of Caffeine, 8-Chlorotheophylline and Diphenhydramine by Isocratic High-Performance Liquid Chromatography: Stress Test for Stability Evaluation. Journal of Chromatography A, 870, 97-103. http://dx.doi.org/10.1016/S0021-9673(99)01186-3
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Shoukry, A.F., Badawy, S.S. and Issa, Y.M. (1987) Diphenhydramine-Sensitive Membrane Electrodes Based on Poly(vinylchloride) Matrices and Their Use in Drug Analysis. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 23, 29-36. http://dx.doi.org/10.1016/0022-0728(87)85003-9
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Okamoto, H., Uetake, A., Tamaya, R., Nakajima, T., Sagara, K. and Ito, Y. (2001) Simultaneous Determination of Ingredients in an Ointment by Hydrophobic Interaction Electrokinetic Chromatography. Journal of Chromatography A, 929, 133-141. http://dx.doi.org/10.1016/S0021-9673(01)01178-5
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Hodgkinson, L.C., Johnson, M.R., Leigh, S.J., Spencer, N. and Sutherland, I.O. (1979) Formation of Complexes between Aza Derivatives of Crown Ethers and Primary Alkylammonium Salts. Part 4. Diaza-18-Crown-6 Derivatives. Journal of the Chemical Society, Perkin Transactions I, 1979, 2193-2202. http://dx.doi.org/10.1039/p19790002193
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Zareh, M.M. (2010) Compact Cell for the Selective Determination of Ascorbic Acid. Sensor Letters, 8, 1-8. http://dx.doi.org/10.1166/sl.2010.1321
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Guilbault, G., Drust, R., Frant, M., Freiser, H., Hansen, H., Light, T., Pongor, E., Rechnitz, G., Rice, N., Rhom, T., Simon, W. and Thomas, J. (1976) Recommendation for Nomenclature of Ion-Selective Electrodes. Pure and Applied Chemistry, 48, 127-132.
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Zareh, M. (2008) Relative Selectivity Concept of Atropine Selective Electrodes. Analytical Sciences, 24, 889-894. http://dx.doi.org/10.2116/analsci.24.889
