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PLOS Medicine  2016 

Evidence for Community Transmission of Community-Associated but Not Health-Care-Associated Methicillin-Resistant Staphylococcus Aureus Strains Linked to Social and Material Deprivation: Spatial Analysis of Cross-sectional Data

DOI: 10.1371/journal.pmed.1001944

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Abstract:

Background Identifying and tackling the social determinants of infectious diseases has become a public health priority following the recognition that individuals with lower socioeconomic status are disproportionately affected by infectious diseases. In many parts of the world, epidemiologically and genotypically defined community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) strains have emerged to become frequent causes of hospital infection. The aim of this study was to use spatial models with adjustment for area-level hospital attendance to determine the transmission niche of genotypically defined CA- and health-care-associated (HA)-MRSA strains across a diverse region of South East London and to explore a potential link between MRSA carriage and markers of social and material deprivation. Methods and Findings This study involved spatial analysis of cross-sectional data linked with all MRSA isolates identified by three National Health Service (NHS) microbiology laboratories between 1 November 2011 and 29 February 2012. The cohort of hospital-based NHS microbiology diagnostic services serves 867,254 usual residents in the Lambeth, Southwark, and Lewisham boroughs in South East London, United Kingdom (UK). Isolates were classified as HA- or CA-MRSA based on whole genome sequencing. All MRSA cases identified over 4 mo within the three-borough catchment area (n = 471) were mapped to small geographies and linked to area-level aggregated socioeconomic and demographic data. Disease mapping and ecological regression models were used to infer the most likely transmission niches for each MRSA genetic classification and to describe the spatial epidemiology of MRSA in relation to social determinants. Specifically, we aimed to identify demographic and socioeconomic population traits that explain cross-area extra variation in HA- and CA-MRSA relative risks following adjustment for hospital attendance data. We explored the potential for associations with the English Indices of Deprivation 2010 (including the Index of Multiple Deprivation and several deprivation domains and subdomains) and the 2011 England and Wales census demographic and socioeconomic indicators (including numbers of households by deprivation dimension) and indicators of population health. Both CA-and HA-MRSA were associated with household deprivation (CA-MRSA relative risk [RR]: 1.72 [1.03–2.94]; HA-MRSA RR: 1.57 [1.06–2.33]), which was correlated with hospital attendance (Pearson correlation coefficient [PCC] = 0.76). HA-MRSA was also associated with poor health (RR: 1.10

 References

[1]  Semenza JC, Giesecke J. Intervening to reduce inequalities in infections in Europe. American journal of public health. 2008;98(5):787–92. doi: 10.2105/AJPH.2007.120329. pmid:18381991
[2]  Semenza JC. Strategies to intervene on social determinants of infectious diseases. Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2010;15(27):32–9.
[3]  Gillespie IA, Mook P, Little CL, Grant KA, McLauchlin J. Human listeriosis in England, 2001–2007: association with neighbourhood deprivation. Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2010;15(27):7–16.
[4]  Bagger JP, Zindrou D, Taylor KM. Postoperative infection with meticillin-resistant Staphylococcus aureus and socioeconomic background. Lancet. 2004;363(9410):706–8. pmid:15001331 doi: 10.1016/s0140-6736(04)15647-x
[5]  Commission of the European Communities. White paper. Together for Health: A strategic approach for the EU 2008–2013. Brussels; 2007.
[6]  Semenza JC, Suk JE, Tsolova S. Social determinants of infectious diseases: a public health priority. Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2010;15(27):2–4.
[7]  Otter JA, French GL. Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Europe. The Lancet Infectious diseases. 2010;10(4):227–39. doi: 10.1016/S1473-3099(10)70053-0. pmid:20334846
[8]  Herold BC, Immergluck LC, Maranan MC, Lauderdale DS, Gaskin RE, Boyle-Vavra S, et al. Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. Jama. 1998;279(8):593–8. pmid:9486753 doi: 10.1001/jama.279.8.593
[9]  Lowy FD. Staphylococcus aureus infections. New Engl J Med. 1998;339:520–32. pmid:9709046 doi: 10.1056/nejm199808203390806
[10]  Coia JE, Duckworth GJ, Edwards DI, Farrington M, Fry C, Humphreys H, et al. Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. The Journal of hospital infection. 2006;63 Suppl 1:S1–44. pmid:16581155 doi: 10.1016/j.jhin.2006.01.001
[11]  Harbarth S, Sax H, Fankhauser-Rodriguez C, Schrenzel J, Agostinho A, Pittet D. Evaluating the probability of previously unknown carriage of MRSA at hospital admission. The American journal of medicine. 2006;119(3):275 e15-23. doi: 10.1016/j.amjmed.2005.04.042
[12]  Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, Etienne J, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. Jama. 2003;290(22):2976–84. pmid:14665659 doi: 10.1001/jama.290.22.2976
[13]  Egea AL, Gagetti P, Lamberghini R, Faccone D, Lucero C, Vindel A, et al. New patterns of methicillin-resistant Staphylococcus aureus (MRSA) clones, community-associated MRSA genotypes behave like healthcare-associated MRSA genotypes within hospitals, Argentina. International journal of medical microbiology: IJMM. 2014;304(8):1086–99. doi: 10.1016/j.ijmm.2014.08.002. pmid:25240872
[14]  Popovich KJ, Weinstein RA. Commentary: The graying of methicillin-resistant Staphylococcus aureus. Infection control and hospital epidemiology. 2009;30(1):9–12. doi: 10.1086/592709. pmid:19046052
[15]  Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2008;46(6):787–94. doi: 10.1086/528716
[16]  Otter JA, French GL. Community-associated meticillin-resistant Staphylococcus aureus strains as a cause of healthcare-associated infection. The Journal of hospital infection. 2011;79(3):189–93. doi: 10.1016/j.jhin.2011.04.028. pmid:21741111
[17]  Chua K, Laurent F, Coombs G, Grayson ML, Howden BP. Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA—its evolving antimicrobial resistance and implications for therapy. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2011;52(1):99–114. doi: 10.1093/cid/ciq067
[18]  Millar BC, Loughrey A, Elborn JS, Moore JE. Proposed definitions of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA). The Journal of hospital infection. 2007;67(2):109–13. pmid:17669546 doi: 10.1016/j.jhin.2007.06.003
[19]  Otter JA, French GL. Community-associated meticillin-resistant Staphylococcus aureus: the case for a genotypic definition. The Journal of hospital infection. 2012;81(3):143–8. doi: 10.1016/j.jhin.2012.04.009. pmid:22622448
[20]  Zetola N, Francis JS, Nuermberger EL, Bishai WR. Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. The Lancet Infectious diseases. 2005;5(5):275–86. pmid:15854883 doi: 10.1016/s1473-3099(05)70112-2
[21]  Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW. Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med. 2010;7(1):e1000215. doi: 10.1371/journal.pmed.1000215. pmid:20084094
[22]  Tiemersma EW, Bronzwaer SL, Lyytikainen O, Degener JE, Schrijnemakers P, Bruinsma N, et al. Methicillin-resistant Staphylococcus aureus in Europe, 1999–2002. Emerging infectious diseases. 2004;10(9):1627–34. pmid:15498166 doi: 10.3201/eid1009.040069
[23]  Johnson AP, Davies J, Guy R, Abernethy J, Sheridan E, Pearson A, et al. Mandatory surveillance of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in England: the first 10 years. The Journal of antimicrobial chemotherapy. 2012;67(4):802–9. doi: 10.1093/jac/dkr561. pmid:22223229
[24]  Derde LP, Cooper BS, Goossens H, Malhotra-Kumar S, Willems RJ, Gniadkowski M, et al. Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. The Lancet Infectious diseases. 2014;14(1):31–9. doi: 10.1016/S1473-3099(13)70295-0. pmid:24161233
[25]  Lee AS, Cooper BS, Malhotra-Kumar S, Chalfine A, Daikos GL, Fankhauser C, et al. Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial. BMJ open. 2013;3(9):e003126. doi: 10.1136/bmjopen-2013-003126. pmid:24056477
[26]  Harris SR, Cartwright EJ, Torok ME, Holden MT, Brown NM, Ogilvy-Stuart AL, et al. Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. The Lancet Infectious diseases. 2013;13(2):130–6. doi: 10.1016/S1473-3099(12)70268-2. pmid:23158674
[27]  Bastin L, Rollason J, Hilton A, Pillay D, Corcoran C, Elgy J, et al. Spatial aspects of MRSA epidemiology: a case study using stochastic simulation, kernel estimation and SaTScan. Int J Geogr Inf Sci. 2007;21(7):811–36. doi: 10.1080/13658810601135767
[28]  Gray RR, Tatem AJ, Johnson JA, Alekseyenko AV, Pybus OG, Suchard MA, et al. Testing Spatiotemporal Hypothesis of Bacterial Evolution Using Methicillin-Resistant Staphylococcus aureus ST239 Genome-wide Data within a Bayesian Framework. Mol Biol Evol. 2011;28(5):1593–603. doi: 10.1093/molbev/msq319. pmid:21112962
[29]  Hughes J, Stabler R, Gaunt M, Karadag T, Desai N, Betley J, et al. Clonal variation in high- and low-level phenotypic and genotypic mupirocin resistance of MRSA isolates in south-east London. The Journal of antimicrobial chemotherapy. 2015. dkv248–. doi: 10.1093/jac/dkv248.
[30]  UK Data Service Census Support. Office for National Statistics, 2011 Census: Aggregate data (England and Wales). . Licensed under the terms of the Open Government Licence. [].
[31]  Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754–60. doi: 10.1093/bioinformatics/btp324. pmid:19451168
[32]  Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. Journal of molecular biology. 1990;215(3):403–10. pmid:2231712 doi: 10.1016/s0022-2836(05)80360-2
[33]  Miller CE, Batra R, Cooper BS, Patel AK, Klein J, Otter JA, et al. An association between bacterial genotype combined with a high-vancomycin minimum inhibitory concentration and risk of endocarditis in methicillin-resistant Staphylococcus aureus bloodstream infection. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2012;54(5):591–600. doi: 10.1093/cid/cir858
[34]  Office for National Statistics, 2011 Census: Digitised Boundary Data (England and Wales). UK Data Service Census Support.
[35]  UK Data Service Census Support. Office for National Statistics. GeoConvert. .
[36]  English indices of deprivation 2010. Department for Communities and Local Government—Publications—GOV.UK. .
[37]  Health and Social Care Information Centre (HSCIC). Hospital Episode Statistics. .
[38]  Rue H, Martino S, Chopin N. Approximate Bayesian inference for latent Gaussian models by using integrated nested Laplace approximations. J R Stat Soc B. 2009;71:319–92. doi: 10.1111/j.1467-9868.2008.00700.x
[39]  R Core Team. R: A Language and Environment for Statistical Computing Vienna, Austria: R Foundation for Statistical Computing; 2013.
[40]  Rue H, Martino S. Approximate Bayesian inference for hierarchical Gaussian Markov random field models. J Stat Plan Infer. 2007;137(10):3177–92. doi: 10.1016/j.jspi.2006.07.016
[41]  Roos M, Held L. Sensitivity analysis in Bayesian generalized linear mixed models for binary data. Bayesian Anal. 2011;6(2):259–78. doi: 10.1214/11-ba609
[42]  Schrodle B, Held L, Riebler A, Danuser J. Using integrated nested Laplace approximations for the evaluation of veterinary surveillance data from Switzerland: a case-study. J R Stat Soc C-Appl. 2011;60:261–79. doi: 10.1111/j.1467-9876.2010.00740.x
[43]  Blangiardo M, Cameletti M, Baio G, Rue H. Spatial and spatio-temporal models with R-INLA. Spatial and spatio-temporal epidemiology. 2013;7:39–55. pmid:24377114 doi: 10.1016/j.sste.2012.12.001
[44]  Besag J, York J, Mollie A. Bayesian Image-Restoration, with 2 Applications in Spatial Statistics. Ann I Stat Math. 1991;43(1):1–20. doi: 10.1007/bf00116466
[45]  S B . Revisiting Spherical Trigonometry with Orthogonal Projectors. Math Assoc Am Coll Math J. 2004;35:375–81. doi: 10.2307/4146847
[46]  Bivand R, Lewin-Koh N. Maptools: Tools for reading and handling spatial objects. 2014.
[47]  Bivand R, Hauke J, Kossowski T. Computing the Jacobian in Gaussian Spatial Autoregressive Models: An Illustrated Comparison of Available Methods. Geogr Anal. 2013;45(2):150–79. doi: 10.1111/gean.12008
[48]  Bivand R, Piras G. Comparing Implementations of Estimation Methods for Spatial Econometrics. J Stat Softw. 2015;63(18):1–36. doi: 10.18637/jss.v063.i18
[49]  Rue H MS, Chopin N, Sara Martino NC. Implementing approximate Bayesian inference for latent Gaussian models using integrated nested Laplace approximations: A manual for the inla-program. J R Stat Soc Ser B (Statistical Methodol). 2009(71):319–92. doi: 10.1111/j.1467-9868.2008.00700.x
[50]  Bjornstad ON. Ncf: spatial nonparametric covariance functions. 2013.
[51]  Csardi G NT. The igraph software package for complex network research. InterJournal. 2006;Complex Systems:1695.
[52]  Hota B, Ellenbogen C, Hayden MK, Aroutcheva A, Rice TW, Weinstein RA. Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections at a public hospital: do public housing and incarceration amplify transmission? Archives of internal medicine. 2007;167(10):1026–33. pmid:17533205 doi: 10.1001/archinte.167.10.1026
[53]  Popovich KJ, Smith KY, Khawcharoenporn T, Thurlow CJ, Lough J, Thomas G, et al. Community-associated methicillin-resistant Staphylococcus aureus colonization in high-risk groups of HIV-infected patients. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2012;54(9):1296–303. doi: 10.1093/cid/cis030
[54]  Bratu S, Landman D, Gupta J, Trehan M, Panwar M, Quale J. A population-based study examining the emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 in New York City. Annals of clinical microbiology and antimicrobials. 2006;5:29. pmid:17137512
[55]  Casey JA, Cosgrove SE, Stewart WF, Pollak J, Schwartz BS. A population-based study of the epidemiology and clinical features of methicillin-resistant Staphylococcus aureus infection in Pennsylvania, 2001–2010. Epidemiology and infection. 2013;141(6):1166–79. doi: 10.1017/S0950268812001872. pmid:22929058
[56]  Huggan PJ, Wells JE, Browne M, Richardson A, Murdoch DR, Chambers ST. Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Internal medicine journal. 2010;40(2):117–25. doi: 10.1111/j.1445-5994.2009.01910.x. pmid:19226421
[57]  Tong SY, van Hal SJ, Einsiedel L, Currie BJ, Turnidge JD. Impact of ethnicity and socio-economic status on Staphylococcus aureus bacteremia incidence and mortality: a heavy burden in Indigenous Australians. BMC infectious diseases. 2012;12:249. doi: 10.1186/1471-2334-12-249. pmid:23043704
[58]  Tong SY, Bishop EJ, Lilliebridge RA, Cheng AC, Spasova-Penkova Z, Holt DC, et al. Community-associated strains of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus in indigenous Northern Australia: epidemiology and outcomes. The Journal of infectious diseases. 2009;199(10):1461–70. doi: 10.1086/598218. pmid:19392622
[59]  Popovich KJ, Weinstein RA, Aroutcheva A, Rice T, Hota B. Community-associated methicillin-resistant Staphylococcus aureus and HIV: intersecting epidemics. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2010;50(7):979–87. doi: 10.1086/651076
[60]  Murphy CR, Hudson LO, Spratt BG, Elkins K, Terpstra L, Gombosev A, et al. Predictors of hospitals with endemic community-associated methicillin-resistant Staphylococcus aureus. Infection control and hospital epidemiology. 2013;34(6):581–7. doi: 10.1086/670631. pmid:23651888
[61]  Golding GR, Levett PN, McDonald RR, Irvine J, Nsungu M, Woods S, et al. A comparison of risk factors associated with community-associated methicillin-resistant and -susceptible Staphylococcus aureus infections in remote communities. Epidemiology and infection. 2010;138(5):730–7. doi: 10.1017/S0950268809991488. pmid:20092664
[62]  Johnson AP. Methicillin-resistant Staphylococcus aureus: the European landscape. The Journal of antimicrobial chemotherapy. 2011;66 Suppl 4:iv43–iv8. doi: 10.1093/jac/dkr076. pmid:21521706
[63]  Ellington MJ, Hope R, Livermore DM, Kearns AM, Henderson K, Cookson BD, et al. Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007. The Journal of antimicrobial chemotherapy. 2010;65(3):446–8. doi: 10.1093/jac/dkp448. pmid:20035019
[64]  Edgeworth JD. Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care. The Journal of antimicrobial chemotherapy. 2011;66 Suppl 2:ii41–7. doi: 10.1093/jac/dkq325. pmid:20852273
[65]  David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clinical microbiology reviews. 2010;23(3):616–87. doi: 10.1128/CMR.00081-09. pmid:20610826
[66]  DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375(9725):1557–68. doi: 10.1016/S0140-6736(09)61999-1. pmid:20206987
[67]  Bartels MD, Kristoffersen K, Boye K, Westh H. Rise and subsequent decline of community-associated methicillin resistant Staphylococcus aureus ST30-IVc in Copenhagen, Denmark through an effective search and destroy policy. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2010;16(1):78–83. doi: 10.1111/j.1469-0691.2009.02829.x
[68]  Urth T, Juul G, Skov R, Schonheyder HC. Spread of a methicillin-resistant Staphylococcus aureus ST80-IV clone in a Danish community. Infection control and hospital epidemiology. 2005;26(2):144–9. pmid:15756884 doi: 10.1086/502518
[69]  Greenland S, Morgenstern H. Ecological bias, confounding, and effect modification. International journal of epidemiology. 1989;18(1):269–74. pmid:2656561 doi: 10.1093/ije/18.1.269
[70]  Greenland S. Divergent biases in ecologic and individual-level studies. Statistics in medicine. 1992;11(9):1209–23. pmid:1509221 doi: 10.1002/sim.4780110907
[71]  Gonzalez BE, Rueda AM, Shelburne SA, 3rd, Musher DM, Hamill RJ, Hulten KG. Community-associated strains of methicillin-resistant Staphylococccus aureus as the cause of healthcare-associated infection. Infection control and hospital epidemiology. 2006;27(10):1051–6.
[72]  Agata EM, Webb GF, Horn MA, Moellering RC, Jr., Ruan S. Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2009;48(3):274–84. doi: 10.1086/595844
[73]  Skov RL, Jensen KS. Community-associated meticillin-resistant Staphylococcus aureus as a cause of hospital-acquired infections. The Journal of hospital infection. 2009;73(4):364–70. doi: 10.1016/j.jhin.2009.07.004. pmid:19786313

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