Novel triblock copolymers of poly (L-lactide)-poly
(ethylene glycol)-sebacate-poly (ethylene glycol)-poly (L-lactide) were
synthesized by Ring-Opening Polymerization of different ratios of L-lactide with
other three pre-prepared poly (ethylene glycol)-sebacate-poly (ethylene glycol)
polymers, coded A, B and C which had different poly (ethyleneglycol) chain
lengths. The copolymers were characterized by FTIR and 1H NMR
spectroscopy, which indicated that the reaction of ROP took place and led to
producing nine triblock copolymers having new different lactide chain lengths
(n = 10, 25 and 50), AL10, AL25, AL50,BL10,
BL25, BL50, CL10, CL25, and CL50.
Nine polymer networks were also prepared from copolymers with sodium alginate S1- S9 and finally mixed with a
solution of hydroxyl ethyl cellulose to form SH1 - SH9.
References
[1]
He, X., Liang, L., Xie, M., Zhang, Y., Lin, Sh. and Yan, D. (2007) Synthesis of Novel Linear PEO-b-PS-b-PCL Triblock Copolymers by the Combination of ATRP, ROP, and a Click Reaction. Macromolecular Chemistry and Physics, 208, 1797-1802.
[2]
Namekawa, S., Suda, S., Yama, H. and Kobyashi, S. (1999) Lipase-Catalyzed Ring-Opening Polymerization of Lactones to Polyesters and Its Mechanistic Aspects. International Journal of Biological Macromolecules, 25, 145-151. https://doi.org/10.1016/S0141-8130(99)00028-8
[3]
Kikuchi, H., Uyama, H. and Kobayashi, S. (2002) Lipase-Catalyzed Ring-Opening Polymerization of Substituted Lactones. Polymer Journal, 34, 835-840.
https://doi.org/10.1295/polymj.34.835
[4]
Yu, Y., Storti, G. and Morbidelli, M. (2009) Ring-Opening Polymerization L-Lactide: Kinetic and Modeling Study. Macromolecules, 42, 8187-8197.
https://doi.org/10.1021/ma901359x
[5]
Todd, R. (2013) Catalyst and Monomer Design: Targeting Polymer Properties via Organic Catalyzed Ring Opening Polymerization, Ph.D. Thesis, The University of Warwick, Coventry, UK.
[6]
Coulembier, O., Moin, S., Raquez, J., Meyer, F., Mespouille, L. and Duquese, E. (2011) Thermal Degradation of Poly(L-Actide): Accelerating Effect of Residual DBU Based Organic Catalysts. Polymer Degradation and Stability, 96, 739-744.
https://doi.org/10.1016/j.polymdegradstab.2011.02.014
[7]
Lohmeijer, B., Pratt, R., Leibfarth, F., Logean, J., Long, D., Dove, A., Nederberg, F., Choi, J., Wade, C., Waymouth, R. and Hedrick, J. (2006) Guanidine and Amidine Organocatalyst for Ring-Opening Polymerization of Cyclic Esters. Macromolecules, 39, 8574-8583.
https://doi.org/10.1021/ma0619381
[8]
Qian, H., Wohl, A., Crow, J., Macosko, C. and Hoye, T. (2011) Strategy for Control of Random Copolymerization of Lactide and Glycolide: Application to Synthesis of PEG-b-PLGA Block Polymers Having Narrow Dispersity. Macromolecules, 44, 7132-7140.
https://doi.org/10.1021/ma201169z
[9]
Lim, Y., Heo, G., Cho, S. and Wooley, K. (2013) Construction of Reactive Diblock Copolymer, Polyphosphoester-block-poly(L-lactide), as a Versatile Framework for Functional Materials that Capable of full Degradation and Nanoscopic Assembly Formation. ACS Macro Letters, 2, 785-789.
[10]
Zepoon, M.H. (2013) Biodegradability Studies of a Dipyl and Sebcoyl Copolymers Prepared with Ethylene Glycol Monomers and Polymers. M.Sc. Thesis, University of Basrah, Basrah, Iraq.
[11]
Wang, D., Fredericks, P., Haddad. A., Hill, J., Rasoul, F. and Whittaker, A. (2011) Hydrolytic Degradation of POSS-PEG-Lactide Hybrid Hydrogels. Polymer Degradation and Stability, 96, 123-130. https://doi.org/10.1016/j.polymdegradstab.2010.10.005
[12]
Rachmawati, H. and Permatasari, D. (2008) Development of Papain Microcapsule Using Na-alginate and Study on the in Vitro and ex Vivo Release of Protein from the Microcapsule. 7th Central European Symposium on Pharmaceutical Technology and Biodelivery Systems, Farmacevtski Vesttnikl, 59, 106.
[13]
Mahir A.J. and Al-Lami, H.S. (2014) New Limited Molecular Weight Polymeric Dispersants Prepared by Melt Condensation Polymerization. Chemistry and Materials Research, 6, 12-18.
[14]
Zhao, H., Liu, Z., Park, S., Kim, S. and Piao, L. (2012) Preparation and Characterization of PEG/PLA Multiblock and Triblock Copolymer. Bulletin of the Korean Chemical Society, 33, 1638-1642. https://doi.org/10.5012/bkcs.2012.33.5.1638
[15]
Singh, V. (2008) Synthesis of Poly Lactide with Varying Moleculare Weight. And Aliphatic Content: Effect of Mosture Sorption. M.Sc. Thesis, Drexel University, Philadelphia, USA.
[16]
Patel, A., Gaharwar, A., Iviglia, G., Zhang, H., Mukundan, S., Mihaila, S., Demarchi, D. and Hossein, A.K. (2013) Highly Elastomeric Poly Glycerol Sebacate-co-Poly (Ethylene Glycol) Amphiphilic Block Polymer. Biomaterials, 24, 3970-3983.
https://doi.org/10.1016/j.biomaterials.2013.01.045
[17]
Reddy R. and Reddy, S. (2010) Effect of Different Co-Polymers on Sodium Alginate Microcapsules Containing Isoniazid. International Journal of PharmTech Research, 2, 2198-2203.
[18]
Caykara, T., Demirci, S., Eroglu, M. and Guven, O. (2005) Poly (Ethylene Oxide) and Its Blends with Sodium Alginate. Polymer, 46, 10750-10757.
https://doi.org/10.1016/j.polymer.2005.09.041
[19]
Ferruti, P., Penco, M., Addato, D., Ranucci, E. and Deghenghi, R. (1995) Synthesis and Properties of Novel Block Copolymers Containing Poly(Lactic-Glycolic Acid) and Poly (Ethylene Glycol) Segments. Biomaterials, 16, 1423-1428.
https://doi.org/10.1016/0142-9612(95)96879-5
[20]
Jiang, W. and Schwendeman, S. (2001) Stabilization and Controlled Release of Bovine Serum Albumin Encapsulated in Poly(D, L-Lactide) and Poly(Ethylene Glycol) Microsphere Blends. Pharmaceutical Research, 18, 878-885. https://doi.org/10.1023/A:1011009117586
