Neuroblastoma (NBL) is one
of the most common solid tumors and around 15% of cancer mortality in children.
Amplification of the N-Myc proto-oncogene is strongly correlated with
advanced disease and poor clinical outcome in NBL. Recent studies described
that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with
N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that
in-turn potentiates N-Myc
function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.
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