This short communication is an overview and revision of previous published papers about the relative and absolute stereochemistry of hyperforin and discovery of a new isomer of hyperforin that has been named perforatrin.
References
[1]
Brondz, I. (1979) Antibiotikumet “Hyperforin” og andre innholdsstoffer i drogen Hypricum perforatum L. Thesis (Cand. Pharm.). University of Oslo, Oslo. (In Norwegian)
[2]
Gurevich, A.I., Dobrynin, V.N., Kolosov, M.N., Popravko, S.A., Ryabova, I.D., Chernov, B.K., Derbentseva, N.A., Aizenman, B.E. and Garagulya, A.D. (1971) Hyperforin, an Antibiotic from Hypericum perforatum L. Antibiotiki Kimioterapi, 16, 510-513.
[3]
Brondz, I. (1986) Lecture Entitled: The Influence of Hyperforin on Phagocytosis of E. coli by Human Polymorphonuclear Neutrophils in Vitro. Norlaendska Infektionssjkdomar Symposium, Varmoteti Sundsvall, 14-15 May 1986.
https://www.researchgate.net/publication/233795016_The_influence_of_hyperforin_on_ph agocyto-sis_of_Ecoli_by_human_polymorphonuclear_neutrophils_in_vitro
[4]
Brondz, I. (1987) Influence of Hyperforin upon Phagocytic Functions in Human Polymorphonuclear Leucocytes. 4th International Conference on Chemistry and Biotechnology of Biological Active Natural Products, Budapest, 10-14 August 1987, 119.
[5]
Brondz, I. (2012) Enhancement of the Immunity in AIDS and Other Immunocompromised Patients by Hyperforin an Antibiotic from Hypericum perforatum L. 2nd ARIP European Conference on Anti-microbial Resistance & Infection Prevention, Vilnius, 4-5 October 2012, 60.
[6]
Brondz, I. and Brondz, A. (2012) Recent Enhancement of the Immunity in AIDS and Other Immunocompromised Patients by Hyperforin an Antibiotic from Hypericum perforatum L. (In Vitro Model) Part I. Journal of Biophysical Chemistry, 3, 304-310. https://doi.org/10.4236/jbpc.2012.34037
[7]
Bystrov, N.S., Chernov, B.K., Dobrynin, V.N. and Kolosov, M.N. (1975) The Structure of Hyperforin. Tetrahedron Letters, 16, 2791-2794.
https://doi.org/10.1016/S0040-4039(00)75241-5
[8]
Bystrov, N.S., Dobrynin, V.N., Kolosov, M.N., Chernov, B.K., Chervin, I.I. and Yakovlev, G.I. (1976) Stereokhimiya Antibiotika Hyperforina. Doklady Akademii Nauk SSSR, 226, 338-341.
[9]
Brondz, I. (2017) Super Antibiotics, Part IV. Hyperforin, Relative and Absolute Stereochemistry Elucidated by Gas-Chromatography Mass-Spectrometry with Supersonic Molecular Beams. International Journal of Analytical Mass Spectrometry and Chromatography, 5, 70-85. https://doi.org/10.4236/ijamsc.2017.53005
[10]
Brondz, I., Greibrokk, T., Groth, P.A. and Aasen, A.J. (1982) The Relative Stereochemistry of Hyperforin—An Antibiotic from Hypericum perforatum L. Tetrahedron Letters, 23, 1299-1300. https://doi.org/10.1016/S0040-4039(00)87088-4
[11]
Brondz, I., Greibrokk, T., Groth, P. and Aasen, A.J. (1983) The Absolute Configuration of Hyperforin, an Antibiotic from Hypericum perforatum L., Based on the Crystal Structure Determination of its p-Bromobenzoate Ester. Acta Chemica Scandinavica, A37, 263-265. https://doi.org/10.3891/acta.chem.scand.37a-0263
[12]
Brondz, I. (2017) Super Antibiotics: Part III. Hyperforin, Revision of the Relative and Absolute Stereochemistry Presented by Bystrov et al. Voice of the Publisher, 3, 15-24. https://doi.org/10.4236/vp.2017.32002
[13]
Shimizu, Y., Shi, S.-L., Usuda, H., Kanai, M. and Shibasaki, M. (2010) Catalytic Asymmetric Total Synthesis of ent-Hyperforin. Angewandte Chemie International Edition, 49, 1103-1106. https://doi.org/10.1002/anie.200906678
[14]
Adam, P., Duilio Arigoni, D., Bacher, A. and Eisenreich, W. (2002) Biosynthesis of Hyperforin in Hypericum perforatum. Journal of Medicinal Chemistry, 45, 4786- 4793. https://doi.org/10.1021/jm0209782
