蛋白酶体激活因子REGγ的肿瘤相关靶蛋白研究进展

摘要 蛋白酶体激活因子REGγ属于蛋白酶体激活因子REG（又名11 S）家族的成员之一，主要是通过激活20 S蛋白酶体以非泛素化和非ATP依赖的方式降解蛋白质.近年来，越来越多的研究表明，REGγ在多种肿瘤中出现了异常表达并与肿瘤的发生发展密切相关.REGγ主要是通过降解多种靶蛋白并调控相关的信号通路参与肿瘤的发生发展.本文综述了REGγ在肿瘤中发挥作用的靶蛋白，旨在进一步了解REGγ参与肿瘤发生发展的机制并揭示其作为人类多种肿瘤的诊断标志物和治疗靶点的潜在可能性.
Abstract：The proteasome activator REGγ, which is a member of REG (11 S) proteasome activator family, can stimulate the proteolytic activity of the 20 S core proteasome to degrade proteins independent of ubiquitination and ATP. In recent years, more and more studies show that REGγ is dysregulated in various human cancers and closely related to the oncogenesis and development of cancers. The potential mechanism by which REGγ exerts its role in cancer development is degradation of various target proteins. We now review the target proteins of REGγ in human cancers in order to further understand the mechanism by which REGγ exerts its role in cancer development, and to uncover the potential of REGγ to serve as a new marker for diagnosis and a novel target for treatment in human cancers.