2-氯丙酸微波合成2-氟丙酸及过渡态能垒计算
Microwave Synthesis of 2-Fluoropropionic Acid form 2-Chloropropionic Acid and Energy Barrier Calculation of the Transition State

许多含氟药物具有较强的生理活性。2-氟丙酸是一种具有光学活性的小分子有机酸，且在合成一些药物以及在药物结构修饰中有着重要的生物学意义。用传统方法合成氟代化合物得到目标产物产率较低，且不易纯化。故本文通过微波催化合成方法，改进原始合成方式，改进工艺，提高目标产物的产率。同时，进行了微波反应机理的探讨。
Many fluorine-containing drugs have a strong physiological activity. 2-Fluoropropionic acid is an optically active small molecule organic acid and has important biological significance in the syn-thesis of some drugs and in the modification of drug structure. Since the yield of the target product is low in the conventional method of synthesizing the fluoro-compound and which is not easily pu-rified. Therefore, this paper reported that through microwave catalytic synthesis means to improve the original synthesis, improve the process and the yield of the target product. At the same time, the mechanism of microwave reaction is discussed.