抗菌肽与断奶仔猪的肠道健康
Antimicrobial Peptides and the Gastrointestinal Health of Weaned Piglets

DOI: 10.12677/ACRPVM.2019.84007, PP. 47-54

Keywords: 抗菌肽，断奶仔猪，肠道，生长，健康
Antimicrobial Peptide, Weaned Piglets, Intestinal Tract, Growth, Health

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Abstract:

现代养殖模式下，断奶仔猪的免疫功能尚未发育成熟，加之断奶应激的负面影响较大，因此，为了促进断奶仔猪的生长、防治疾病，生产中通常会使用抗生素。但抗生素滥用造成的药物残留、病原微生物的耐药性等问题，严重威胁畜牧生产和人类健康，迫使人类寻找抗生素的替代物。由于抗菌肽具有抗菌谱广、不易产生耐药性、几乎无毒副作用等优点，使其成为了极有希望替代抗生素的物质。本文从抗菌肽抗病、促生长、改善肠道微生态、改善肠道粘膜，以及提高机体免疫功能等方面综述其在断奶仔猪中的研究进展。
In the modern pig industry, the immune function of piglets has not yet been mature when they are weaned at 3 to 4 weeks of age, and piglets are always challenged by postweaning stress. Therefore, in-feed antibiotic use is a common practice for improving growth performance and preventing disease of weaned piglets. However, the problem of drug residues and drug resistance caused by antibiotic abuse has seriously threatened livestock production and human health, forcing people to find alternatives to antibiotics. Antibacterial peptides have become a promising alternative for antibiotics because they have many advantages, such as broad antimicrobial spectrum, not easy to produce drug resistance, and almost non-toxic effects. Recent progresses on antimicrobial peptide in weaned piglets production will be discussed in this review including the reducing susceptibility to disease, growth promoting, ameliorating intestinal microecology, improvement of the intestinal mucosa, improving the immune function of piglets and prospects.

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