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1-苄基哌啶衍生物的合成研究
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Abstract:
以1-苄基哌啶酮为原料，先与苯胺和三甲基硅氰发生Strecker反应得到化合物2，再经过酰胺化、甲酯化、N-丙酰化等三步反应，以26%的总收率合成了1-苄基哌啶酮衍生物，产物结构经1H NMR、13C NMR和HRMS表征。该方法具有绿色、简便的特点。
The compound 2 was prepared by the Strecker reaction of 1-benzylpiperidone with aniline and trimethylsilyl cyanide. Then 1-benzylpiperidone derivatives were synthesized in 26% overall yield by amidation, methyl esterification and N-propionylation. The structure of the product was characterized by 1H NMR, 13C NMR and HRMS. The method is green and simple.
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