全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

胰腺癌诊疗进展
Advances in Diagnosis and Treatment of Pancreatic Cancer

DOI: 10.12677/HJS.2020.92002, PP. 5-12

Keywords: 胰腺癌,诊断,治疗,进展
Pancreatic Cancer
, Diagnosis, Treatment, Advance

Full-Text   Cite this paper   Add to My Lib

Abstract:

胰腺癌是恶性程度很高的肿瘤,占恶性肿瘤致死原因的第7位。其起病隐匿,发现时一般属于中晚期,预后较差。早发现及早治疗是提高预后的关键。本文对胰腺癌诊断及治疗方面的进展进行综述。
Pancreatic cancer is high degree of malignancy tumor, accounting for the 7th leading cause of death from malignant tumors. Because of its insidious onset, and it is generally in the middle and late stages when found, with a poor prognosis. Early detection and treatment are the key to im-prove the prognosis. This article reviews the advances in diagnosis and treatment of pancreatic cancer.

References

[1]  Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R., Torre, L. and Jemal, A. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal, 68, 394-424.
https://doi.org/10.3322/caac.21492
[2]  Ilic, M. and Ilic, I. (2016) Epidemiology of Pancreatic Cancer. World Journal of Gastroenterology, 22, 9694-9705.
https://doi.org/10.3748/wjg.v22.i44.9694
[3]  Lee, E.S. and Lee, J.M. (2014) Imaging Diagnosis of Pancreatic Cancer: A State-of-the-Art Review. World Journal of Gastroenterology, 20, 7864-7877.
https://doi.org/10.3748/wjg.v20.i24.7864
[4]  Yoon, S.H., Lee, J.M., Cho, J.Y., et al. (2011) Small (≤20 mm) Pancreatic Adenocarcinomas: Analysis of Enhancement Patterns and Secondary Signs with Multiphasic Multide-tector CT. Radiology, 259, 442-452.
https://doi.org/10.1148/radiol.11101133
[5]  Chu, A.J., Lee, J.M., Lee, Y.J., Moon, S.K., Han, J.K. and Choi, B.I. (2012) Dual-Source, Dual-Energy Multidetector CT for the Evaluation of Pancreatic Tumours. The British Journal of Radiology, 85, e891-e898.
https://doi.org/10.1259/bjr/26129418
[6]  Goo, H.W. and Goo, J.M. (2017) Dual-Energy CT: New Horizon in Medical Imaging. Korean Journal of Radiology, 18, 555-569.
https://doi.org/10.3348/kjr.2017.18.4.555
[7]  Agrawal, M.D., Pinho, D.F., Kulkarni, N.M., Hahn, P.F., Guimaraes, A.R. and Sahani, D.V. (2014) Oncologic Applications of Dual-Energy CT in the Abdomen. Radi-oGraphics, 34, 589-612.
https://doi.org/10.1148/rg.343135041
[8]  De Cecco, C.N., Darnell, A., Rengo, M., et al. (2012) Dual-Energy CT: Oncologic Applications. American Journal of Roentgenology, 199, 98-105.
https://doi.org/10.2214/AJR.12.9207
[9]  McLaughlin, P.D., Mallinson, P., Lourenco, P. and Nicolaou, S. (2015) Dual-Energy Computed Tomography: Advantages in the Acute Setting. Radiologic Clinics of North America, 53, 619-638.
https://doi.org/10.1016/j.rcl.2015.02.016
[10]  Marin, D., Nelson, R.C., Barnhart, H., et al. (2010) Detection of Pancreatic Tumors, Image Quality, and Radiation Dose during the Pancreatic Parenchymal Phase: Effect of a Low-Tube-Voltage, High-Tube-Current CT Technique-Preliminary Results. Radiology, 256, 450-459.
https://doi.org/10.1148/radiol.10091819
[11]  Yamamura, S., Oda, S., Utsunomiya, D., et al. (2013) Dynamic Computed Tomography of Locally Advanced Pancreatic Cancer: Effect of Low Tube Voltage and a Hybrid Iterative Reconstruction Algorithm on Image Quality. Journal of Computer Assisted Tomography, 37, 790-796.
https://doi.org/10.1097/RCT.0b013e318296db2b
[12]  Noda, Y., Kanematsu, M., Goshima, S., et al. (2014) Reduction of Iodine Load in CT Imaging of Pancreas Acquired with Low Tube Voltage and an Adaptive Statistical Iterative Reconstruction Technique. Journal of Computer Assisted Tomography, 38, 714-720.
https://doi.org/10.1097/RCT.0000000000000106
[13]  Kim, J.H., Lee, J.M., Park, J.H., et al. (2013) Solid Pancreatic Lesions: Characterization by Using Timing Bolus Dynamic Contrast-Enhanced MR Imaging Assess-ment—A Preliminary Study. Radiology, 266, 185-196.
https://doi.org/10.1148/radiol.12120111
[14]  Bashir, U., Mallia, A., Stirling, J., et al. (2015) PET/MRI in Oncological Imaging: State of the Art. Diagnostics, 5, 333-357.
https://doi.org/10.3390/diagnostics5030333
[15]  Wehrl, H.F., Sauter, A.W., Divine, M.R. and Pichler, B.J. (2015) Combined PET/MR: A Technology Becomes Mature. Journal of Nuclear Medicine, 56, 165-168.
https://doi.org/10.2967/jnumed.114.150318
[16]  Bang, J.Y., Kirtane, S., Krall, K., et al. (2018) In Memori-am-Fine Needle Aspiration, Birth-Fine Needle Biopsy: The Changing Trend in Endoscopic Ultrasound-Guided Tissue Acquisition. Digestive Endoscopy, 31, 197-202.
https://doi.org/10.1111/den.13280
[17]  Zhang, Y., Yang, J., Li, H., Wu, Y., Zhang, H. and Chen, W. (2015) Tumor Markers CA19-9, CA242 and CEA in the Diagnosis of Pancreatic Cancer: A Meta-Analysis. International Journal of Clinical and Experimental Medicine, 8, 11683-11691.
[18]  Halkova, T., Cuperkova, R., Minarik, M. and Benesova, L. (2015) MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Di-agnosis and Prognosis. Gastroenterology Research and Practice, 2015, Article ID: 892903.
https://doi.org/10.1155/2015/892903
[19]  Subramani, R., Gangwani, L., Nandy, S.B., Arumugam, A., Chat-topadhyay, M. and Lakshmanaswamy, R. (2015) Emerging Roles of MicroRNAs in Pancreatic Cancer Diagnosis, Therapy and Prognosis (Review). International Journal of Oncology, 47, 1203-1210.
https://doi.org/10.3892/ijo.2015.3129
[20]  Tian, X., Shivapurkar, N., Wu, Z., et al. (2016) Circulating Mi-croRNA Profile Predicts Disease Progression in Patients Receiving Second-Line Treatment of Lapatinib and Cape-citabine for Metastatic Pancreatic Cancer. Oncology Letters, 11, 1645-1650.
https://doi.org/10.3892/ol.2016.4101
[21]  Bhagwat, N., Dulmage Jr., K., et al. (2018) An Integrated Flow Cytometry-Based Platform for Isolation and Molecular Characterization of Circulating Tumor Single Cells and Clusters. Scientific Reports, 8, 5035.
https://doi.org/10.1038/s41598-018-23217-5
[22]  Gao, Y., Zhu, Y. and Yuan, Z. (2016) Circulating Tumor Cells and Circulating Tumor DNA Provide New Insights into Pancreatic Cancer. International Journal of Medical Sciences, 13, 902-913.
https://doi.org/10.7150/ijms.16734
[23]  Kolostova, K., Rzechonek, A., Schützner, J.A.N. and Grill, R. (2017) Circulating Tumor Cells as an Auxiliary. In Vivo, 31, 1197-1202.
https://doi.org/10.21873/invivo.11190
[24]  Desjobert, C., El Ma?, M., Gérard-Hirne, T., et al. (2015) Combined Analysis of DNA Methylation and Cell Cycle in Cancer Cells. Epigenetics, 10, 82-91.
https://doi.org/10.1080/15592294.2014.995542
[25]  Yi, J.M., Guzzetta, A.A., Bailey, V.J., et al. (2013) Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer. Clinical Cancer Research, 19, 6544-6555.
https://doi.org/10.1158/1078-0432.CCR-12-3224
[26]  Melo, S.A., Luecke, L.B., Kahlert, C., et al. (2015) Glypican1 Identifies Cancer Exosomes and Facilitates Early Detection of Cancer. Nature, 523, 177-182.
https://doi.org/10.1038/nature14581
[27]  Tan, C., Zhang, H., Peng, B. and Li, K. (2015) Outcome and Costs of Laparoscopic Pancreaticoduodenectomy during the Initial Learning Curve vs Laparotomy. World Journal of Gas-troenterology, 21, 5311-5319.
https://doi.org/10.3748/wjg.v21.i17.5311
[28]  Handgraaf, H.J.M., Boonstra, M.C., Van Erkel, A.R., et al. (2014) Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery. BioMed Research International, 2014, 1-8.
https://doi.org/10.1155/2014/890230
[29]  de Werra, C., Quarto, G., Aloia, S., et al. (2015) The Use of In-traoperative Ultrasound for Diagnosis and Stadiation in Pancreatic Head Neoformations. International Journal of Surgery, 21, S55-S58.
https://doi.org/10.1016/j.ijsu.2015.04.091
[30]  Nelson, D.W., Blanchard, T.H., Causey, M.W., et al. (2013) Examining the Accuracy and Clinical Usefulness of Intraoperative Frozen Section Analysis in the Management of Pancreatic Lesions. The American Journal of Surgery, 205, 613-617.
https://doi.org/10.1016/j.amjsurg.2013.01.015
[31]  Vahrmeijer, A.L., Hutteman, M., van der Vorst, J.R., van de Velde, C.J.H. and Frangioni, J.V. (2013) Image-Guided Cancer Surgery Using Near-Infrared Fluorescence. Na-ture Reviews Clinical Oncology, 10, 507-518.
https://doi.org/10.1038/nrclinonc.2013.123
[32]  Yano, S., Hiroshima, Y., Maawy, A., et al. (2015) Col-or-Coding Cancer and Stromal Cells with Genetic Reporters in a Patient-Derived Orthotopic Xenograft (PDOX) Model of Pancreatic Cancer Enhances Fluorescence-Guided Surgery. Cancer Gene Therapy, 22, 344-350.
https://doi.org/10.1038/cgt.2015.26
[33]  Muranaka, T., Kuwatani, M., Komatsu, Y., et al. (2017) Comparison of Efficacy and Toxicity of FOLFIRINOX and Gemcitabine with Nab-Paclitaxel in Unresectable Pancreatic Cancer. Journal of Gastrointestinal Oncology, 8, 566-571.
https://doi.org/10.21037/jgo.2017.02.02
[34]  Han, Q., Deng, M., Lv, Y. and Dai, G. (2017) Survival of Patients with Advanced Pancreatic Cancer after Iodine 125 Seeds Implantation Brachytherapy: A Meta-Analysis. Medicine, 96, e5719.
https://doi.org/10.1097/MD.0000000000005719
[35]  Lauffer, D.C., Kuhn, P.A., Kueng, M., et al. (2018) Pancreatic Cancer: Feasibility and Outcome after Radiochemotherapy with High Dose External Radiotherapy for Non-Resected and R1 Resected Patients. Cureus, 10, 1-7.
https://doi.org/10.7759/cureus.c14
[36]  Ma, N., Wang, Z., Zhao, J., et al. (2017) Improved Survival in Patients with Resected Pancreatic Carcinoma Using Postop-erative Intensity-Modulated Radiotherapy and Regional Intra-Arterial Infusion Chemotherapy. Medical Science Monitor, 23, 2315-2323.
https://doi.org/10.12659/MSM.904393
[37]  Chiorean, E.G. and Coveler, A.L. (2015) Pancreatic Cancer: Optimizing Treatment Options, New, and Emerging Targeted Therapies. Drug Design, Devel-opment and Therapy, 9, 3529-3545.
https://doi.org/10.2147/DDDT.S60328
[38]  Matsuoka, T. and Yashiro, M. (2016) Molecular Targets for the Treatment of Pancreatic Cancer: Clinical and Experimental Studies. World Journal of Gastroenterology, 22, 776-789.
https://doi.org/10.3748/wjg.v22.i2.776
[39]  Furuse, J., Gemma, A., Ichikawa, W., Okusaka, T., Seki, A. and Ishii, T. (2017) Postmarketing Surveillance Study of Erlotinib plus Gem-citabine for Pancreatic Cancer in Japan: POLARIS Final Analysis. Japanese Journal of Clinical Oncology, 47, 832-839.
https://doi.org/10.1093/jjco/hyx075
[40]  Vogl, T.J., Panahi, B., Albrecht, M.H., et al. (2018) Mi-crowave Ablation of Pancreatic Tumors. Minimally Invasive Therapy & Allied Technologies, 27, 33-40.
https://doi.org/10.1080/13645706.2017.1420664
[41]  Strunk, H.M., Henseler, J., Rauch, M., et al. (2016) Clinical Use of High-Intensity Focused Ultrasound (HIFU) for Tumor and Pain Reduction in Advanced Pancreatic Cancer. RoFo, 188, 662-670.
https://doi.org/10.1055/s-0042-105517
[42]  Yang, Y. (2015) Cancer Immunotherapy: Harnessing the Immune System to Battle Cancer Find the Latest Version: Cancer Immunotherapy: Harnessing the Immune System to Battle Cancer. The Journal of Clinical Investigation, 125, 3335-3337.
https://doi.org/10.1172/JCI83871
[43]  Sharpe, M.E. (2018) T-Cell Immunotherapies and the Role of Nonclinical Assessment: The Balance between Efficacy and Pathology. Toxicologic Pathology, 46, 131-146.
https://doi.org/10.1177/0192623317752101

Full-Text

comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413