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L-脯氨酸衍生的新型硫脲催化剂催化苯甲醛的加成烷基化
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Abstract:
本文以L-脯氨酸衍生的手性硫脲为催化剂，对苯甲醛与二乙基锌的不对称1,2-加成烷基化反应进行了研究。我们发现在最优化的催化剂反应条件下，该反应可以以高收率和中等的对映选择性得到1-苯基-1-丙醇化合物。该催化体系具有高效、低成本、反应条件温和等特点，为合成手性芳基醇类化合物提供了一条有效、方便的路径。
In this paper, a series of L-proline derived chiral thioureas were designed and synthesized. Then the resulting catalysts were applied into the 1,2-addition reation of diethylzinc to benzaldehyde, which provided 1-phenylpropan-1-ol with good to excellent yields, albeit with moderate enatioselectivity. The catalytic system is featured with high efficiency, low cost as well as mild reaction conditions, and it was proved to be an effective and convenient route for the synthesis of chiral aromatic alcohols.
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