|
|
快速眼动睡眠期行为障碍相关的帕金森病的影像学生物标志研究进展
|
Abstract:
快速眼动睡眠期行为障碍(REM sleep behaviour disorder, RBD)是一种发生在快速眼动期(rapid eye movement, REM)的一种与梦境相关的复杂行为障碍，特发性快速眼动睡眠期行为障碍(idiopathic RBD, iRBD)与神经变性病如帕金森病(Parkinson’s disease, PD)、路易体痴呆(dementia with Lewy bodies, DLB)、多系统萎缩(multiple system atrophy, MSA)等密切相关，其中帕金森病最多见。iRBD是神经变性病的前驱症状。尽早发现并干预神经变性病显得尤为重要。当前许多研究致力于寻找RBD相关的神经变性病的生物学标志，其中影像学方面的技术因其客观性和快速进展性而成为研究热点。本文旨在将当前的影像学相关的帕金森病前驱症状生物学标志研究进展做一综述。
REM sleep behaveour disorder (RBD) is a complex behavior disorder associated with dreams that occur during rapid eye movement (REM). Idiopathic RBD (iRBD) is closely related to neurodegen-eration such as Parkinson’s disease, Louis dementia, multiple atrophy systems and so on. Among of them, Parkinson’s disease is the most common. iRBD is a precursor to neurodegeneration. It’s par-ticularly important to discover and intervene in neurodegeneration early. Many studies have fo-cused on the biomarkers of RBD-related neurodegeneration, in which imaging techniques have become a hot topic for their objectivity and rapid progress. The aim of this paper is to review the recent advances in imaging-related Parkinson’s disease precursor biomarkers.
| [1] | Dauvilliers, Y., Schenck, C.H., Postuma, R.B., Iranzo, A., Luppi, P.H., Plazzi, G., Montplaisir, J. and Boeve, B. (2018) REM Sleep Behaviour Disorder. Nature Reviews Disease Primers, 4, 19. https://doi.org/10.1038/s41572-018-0016-5 |
| [2] | Castelnovo, A., Lopez, R., Proserpio, P., Nobili, L. and Dauvilliers, Y. (2018) NREM Sleep Parasomnias as Disorders of Sleep-State Dissociation. Nature Reviews Neurology, 14, 470-481. https://doi.org/10.1038/s41582-018-0030-y |
| [3] | Arnaldi, D., Antelmi, E., St Louis, E.K., Postuma, R.B. and Arnulf, I. (2017) Idiopathic REM Sleep Behavior Disorder and Neurodegenerative Risk: To Tell or Not to Tell to the Patient? How to Minimize the Risk? Sleep Medicine Reviews, 36, 82-95. https://doi.org/10.1016/j.smrv.2016.11.002 |
| [4] | Bodkin, C.L. and Schenck, C.H. (2009) Rapid Eye Movement Sleep Behavior Disorder in Women: Relevance to General and Specialty Medical Practice. Journal of Women’s Health, 18, 1955-1963.
https://doi.org/10.1089/jwh.2008.1348 |
| [5] | Kang, S.H., Yoon, I.Y., Lee, S.D., Han, J.W., Kim, T.H. and Kim, K.W. (2013) REM Sleep Behavior Disorder in the Korean Elderly Population: Prevalence and Clinical Characteristics. Sleep, 36, 1147-1152.
https://doi.org/10.5665/sleep.2874 |
| [6] | Iranzo, A., Tolosa, E., Gelpi, E., Molinuevo, J.L., Valldeoriola, F., Ser-radell, M., Sanchez-Valle, R., Vilaseca, I., Lome？a, F., Vilas, D., Lladó, A., Gaig, C. and Santamaria, J. (2013) Neu-rodegenerative Disease Status and Post-Mortem Pathology in Idiopathic Rapid-Eye-Movement Sleep Behaviour Dis-order: An Observational Cohort Study. The Lancet Neurology, 12, 443-453. https://doi.org/10.1016/S1474-4422(13)70056-5 |
| [7] | Rahayel, S., Montplaisir, J., Monchi, O., Bedetti, C., Postuma, R.B., Brambati, S., Carrier, J., Joubert, S., Latreille, V., Jubault, T. and Gagnon, J.F. (2015) Patterns of Cortical Thin-ning in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Movement Disorders, 30, 680-687. https://doi.org/10.1002/mds.25820 |
| [8] | Rahayel, S., Postuma, R.B., Montplaisir, J., Bedetti, C., Brambati, S., Carrier, J., Monchi, O., Bourgouin, P.A., Gaubert, M. and Gagnon, J.F. (2018) Abnormal Gray Matter Shape, Thick-ness, and Volume in the Motor Cortico-Subcortical Loop in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: Association with Clinical and Motor Features. Cerebral Cortex, 28, 658-671. https://doi.org/10.1093/cercor/bhx137 |
| [9] | Pyatigorskaya, N., Gaurav, R., Arnaldi, D., Leu-Semenescu, S., Ya-hia-Cherif, L., Valabregue, R., Vidailhet, M., Arnulf, I. and Lehericy, S. (2017) Magnetic Resonance Imaging Bi-omarkers to Assess Substantia Nigra Damage in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Sleep, 40. https://doi.org/10.1093/sleep/zsx149 |
| [10] | Hanyu, H., Inoue, Y., Sakurai, H., Kanetaka, H., Nakamura, M., Miyamoto, T., Sasai, T. and Iwamoto, T. (2012) Voxel-Based Magnetic Resonance Imaging Study of Structural Brain Changes in Patients with Idiopathic REM Sleep Behavior Disorder. Parkinsonism & Related Disorders, 18, 136-139. https://doi.org/10.1016/j.parkreldis.2011.08.023 |
| [11] | Scherfler, C., Frauscher, B., Schocke, M., Iranzo, A., Gschliesser, V., Seppi, K., Santamaria, J., Tolosa, E., Hogl, B. and Poewe, W. (2011) White and Gray Matter Abnor-malities in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Diffusion-Tensor Imaging and Voxel-Based Morphometry Study. Annals of Neurology, 69, 400-407. https://doi.org/10.1002/ana.22245 |
| [12] | Uchida, Y., Kan, H., Sakurai, K., Arai, N., Kato, D., Kawashima, S., Ueki, Y. and Matsukawa, N. (2019) Voxel-Based Quantitative Susceptibility Mapping in Parkinson's Disease with Mild Cognitive Impairment. Movement Disorders, 34, 1164-1173. https://doi.org/10.1002/mds.27717 |
| [13] | Shahmaei, V., Faeghi, F., Mohammdbeigi, A., Hashemi, H. and Ashrafi, F. (2019) Evaluation of Iron Deposition in Brain Basal Ganglia of Patients with Parkinson’s Disease Using Quantitative Susceptibility Mapping. European Journal of Radiol-ogy Open, 6, 169-174. https://doi.org/10.1016/j.ejro.2019.04.005 |
| [14] | Sun, J., Lai, Z., Ma, J., Gao, L., Chen, M., Chen, J., Fang, J., Fan, Y., Bao, Y., Zhang, D., Chan, P., Yang, Q., Ye, C., Wu, T. and Ma, T. (2019) Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Movement Disorders, 35, 478-485. https://doi.org/10.1002/mds.27929 |
| [15] | Shin, H.Y., Joo, E.Y., Kim, S.T., Dhong, H.J. and Cho, J.W. (2013) Comparison Study of Olfactory Function and Substantia Nigra Hyperechogenicity in Idiopathic REM Sleep Behavior Disorder, Parkinson’s Disease and Normal Control. Neurological Sciences, 34, 935-940. https://doi.org/10.1007/s10072-012-1164-0 |
| [16] | Iranzo, A., Stockner, H., Serradell, M., Seppi, K., Valldeoriola, F., Frauscher, B., Molinuevo, J.L., Vilaseca, I., Mitterling, T., Gaig, C., Vilas, D., Santamaria, J., Hogl, B., Tolosa, E. and Poewe, W. (2014) Five-Year Follow-Up of Substantia Nigra Echogenicity in Idiopathic REM Sleep Behavior Dis-order. Movement Disorders, 29, 1774-1780.
https://doi.org/10.1002/mds.26055 |
| [17] | Iranzo, A., Lome？a, F., Stockner, H., Valldeoriola, F., Vilaseca, I., Salamero, M., Molinuevo, J.L., Serradell, M., Duch, J., Pavía, J., Gallego, J., Seppi, K., H？gl, B., Tolosa, E., Poewe, W. and Santamaria, J. (2010) Decreased Striatal Dopamine Transporter Uptake and Substantia Nigra Hyperechogenicity as Risk Markers of Synucleinopathy in Patients with Idiopathic Rapid-Eye-Movement Sleep Behaviour Disorder: A Pro-spective Study. The Lancet Neurology, 9, 1070-1077. https://doi.org/10.1016/S1474-4422(10)70216-7 |
| [18] | Shen, L.H., Liao, M.H. and Tseng, Y.C. (2012) Recent Advances in Imaging of Dopaminergic Neurons for Evaluation of Neuropsychiatric Disorders. Journal of Biomedicine and Biotechnology, 2012, Article ID: 259349.
https://doi.org/10.1155/2012/259349 |
| [19] | Rupprecht, S., Walther, B., Gudziol, H., Steenbeck, J., Freesmeyer, M., Witte, O.W., Gunther, A. and Schwab, M. (2013) Clinical Markers of Early Nigrostriatal Neurodegeneration in Idio-pathic Rapid Eye Movement Sleep Behavior Disorder. Sleep Medicine, 14, 1064-1070. https://doi.org/10.1016/j.sleep.2013.06.008 |
| [20] | Eisensehr, I., et al. (2003) Increased Muscle Activity during Rapid Eye Movement Sleep Correlates with Decrease of Striatal Presynaptic Dopamine Transporters. IPT and IBZM SPECT Imaging in Subclinical and Clinically Manifest Idiopathic REM Sleep Behavior Disorder, Parkinson’s Disease, and Controls. Sleep, 26, 507-512.
https://doi.org/10.1093/sleep/26.5.507 |
| [21] | Iranzo, A., Valldeoriola, F., Lomena, F., Molinuevo, J.L., Serradell, M., Salamero, M., Cot, A,. Ros, D., Pavia, J., Santamaria, J. and Tolosa, E. (2011) Serial Dopamine Transporter Im-aging of Nigrostriatal Function in Patients with Idiopathic Rapid-Eye-Movement Sleep Behaviour Disorder: A Pro-spective Study. The Lancet Neurology, 10, 797-805.
https://doi.org/10.1016/S1474-4422(11)70152-1 |
| [22] | Ma, Y., Tang, C., Spetsieris, P.G., Dhawan, V. and Eidel-berg, D. (2007) Abnormal Metabolic Network Activity in Parkinson’s Disease: Test-Retest Reproducibility. Journal of Cerebral Blood Flow & Metabolism, 27, 597-605.
https://doi.org/10.1038/sj.jcbfm.9600358 |
| [23] | Eidelberg, D. (2009) Metabolic Brain Networks in Neurodegener-ative Disorders: A Functional Imaging Approach. Trends in Neurosciences, 32, 548-557. https://doi.org/10.1016/j.tins.2009.06.003 |
| [24] | Wu, P., Yu, H., Peng, S., Dauvilliers, Y., Wang, J., Ge, J., Zhang, H., Eidelberg, D., Ma, Y. and Zuo, C. (2014) Consistent Abnormalities in Metabolic Network Activity in Idiopathic Rapid Eye Movement Sleep Behaviour Disorder. Brain, 137, 3122-3128. https://doi.org/10.1093/brain/awu290 |
| [25] | Sokoloff, L. (1977) Relation between Physiological Function and Energy Metabolism in the Central Nervous System. Journal of Neurochemistry, 29, 13-26. https://doi.org/10.1111/j.1471-4159.1977.tb03919.x |
| [26] | Vendette, M., Montplaisir, J., Gosselin, N., Soucy, J.P., Postuma, R.B., Dang-Vu, T.T. and Gagnon, J.F. (2012) Brain Perfusion Anomalies in Rapid Eye Movement Sleep Behavior Disorder with Mild Cognitive Impairment. Movement Disorders, 27, 1255-1261. https://doi.org/10.1002/mds.25034 |
| [27] | Hanyu, H., Inoue, Y., Sakurai, H., Kanetaka, H., Nakamura, M., Miyamoto, T., Sasai, T. and Iwamoto, T. (2011) Regional Cerebral Blood Flow Changes in Patients with Idiopathic REM Sleep Be-havior Disorder. European Journal of Neurology, 18, 784-788. https://doi.org/10.1111/j.1468-1331.2010.03283.x |
| [28] | Vendette, M., Gagnon, J.F., Soucy, J.P., Gosselin, N., Postuma, R.B., Tuineag, M., Godin, I. and Montplaisir, J. (2011) Brain Perfusion and Markers of Neurodegeneration in Rapid Eye Movement Sleep Behavior Disorder. Movement Disorders, 26, 1717-1724. https://doi.org/10.1002/mds.23721 |
| [29] | Xu, J., et al. (2019) Translocator Protein in Late Stage Alzheimer’s Disease and Dementia with Lewy Bodies Brains. Annals of Clinical and Translational Neurology, 6, 1423-1434. |
| [30] | Stokholm, M.G., Iranzo, A., ？stergaard, K., Serradell, M., Otto, M., Svendsen, K.B., Garrido, A., Vilas, D., Borghammer, P., Santamaria, J., M？ller, A., Gaig, C., Brooks, D.J., Tolosa, E. and Pavese, N. (2017) Assessment of Neuroinflammation in Patients with Idiopathic Rapid-Eye-Movement Sleep Behaviour Disorder: A Case-Control Study. The Lancet Neu-rologyogy, 16, 789-796. https://doi.org/10.1016/S1474-4422(17)30173-4 |
| [31] | Chen, Y., Wolk, D.A., Reddin, J.S., Korczykowski, M., Martinez, P.M., Musiek, E.S., Newberg, A.B., Julin, P., Arnold, S.E., Greenberg, J.H. and Detre, J.A. (2011) Voxel-Level Comparison of Arterial Spin-Labeled Perfusion MRI and FDG-PET in Alzheimer Disease. Neurology, 77, 1977-1985. https://doi.org/10.1212/WNL.0b013e31823a0ef7 |
| [32] | Melzer, T.R., Watts, R., MacAskill, M.R., Pearson, J.F., Rueger, S., Pitcher, T.L., Livingston, L., Graham, C., Keenan, R., Shankaranarayanan, A., Alsop, D.C., Dalrymple-Alford, J.C. and Anderson, T.J. (2011) Arterial Spin Labelling Reveals an Abnormal Cerebral Perfusion Pattern in Parkinson’s Disease. Brain, 134, 845-855.
https://doi.org/10.1093/brain/awq377 |
| [33] | Chen, Y., Fan, C., Yang, W., Nie, K., Wu, X., Yang, Y., Yang, Y., Wang, L., Zhang, Y. and Huang, B. (2019) Cortical Hypoperfusion in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder Detected with Arterial Spin-Labeled Perfusion MRI. Neurological Sciences. https://doi.org/10.1007/s10072-019-04118-5 |
| [34] | Logothetis, N.K. (2003) The Underpinnings of the BOLD Functional Magnetic Resonance Imaging Signal. Journal of Neuroscience, 23, 3963-3971. https://doi.org/10.1523/JNEUROSCI.23-10-03963.2003 |
| [35] | Hacker, C.D., Perlmutter, J.S., Criswell, S.R., Ances, B.M. and Snyder, A.Z. (2012) Resting State Functional Connectivity of the Striatum in Parkinson’s Disease. Brain, 135, 3699-3711. https://doi.org/10.1093/brain/aws281 |
| [36] | Ellmore, T.M., Castriotta, R.J., Hendley, K.L., Aalbers, B.M., Furr-Stimming, E., Hood, A.J., Suescun, J., Beurlot, M.R., Hendley, R.T. and Schiess, M.C. (2013) Altered Nigrostriatal and Nigrocortical Functional Connectivity in Rapid Eye Movement Sleep Behavior Disorder. Sleep, 36, 1885-1892. https://doi.org/10.5665/sleep.3222 |
| [37] | Nobili, F., Abbruzzese, G., Morbelli, S., Marchese, R., Girtler, N., Dessi, B., Brugnolo, A., Canepa, C., Drosos, G.C., Sambuceti, G. and Rodriguez, G. (2009) Amnestic Mild Cog-nitive Impairment in Parkinson’s Disease: A Brain Perfusion SPECT Study. Movement Disorders, 24, 414-421. https://doi.org/10.1002/mds.22381 |
| [38] | Postuma, R.B., Iranzo, A., Hu, M., Hogl, B., Boeve, B.F., Manni, R., Oertel, W.H., Arnulf, I., Ferini-Strambi, L., Puligheddu, M., Antelmi, E., Cochen De Cock, V., Arnaldi, D., Mollenhauer, B., Videnovic, A., Sonka, K., Jung, K.Y., Kunz, D., Dauvilliers, Y., Provini, F., Lewis, S.J., Buskova, J., Pavlova, M., Heidbreder, A., Montplaisir, J.Y., Santamaria, J., Barber, T.R., Stefani, A., St Louis, E.K., Terzaghi, M., Janzen, A., Leu-Semenescu, S., Plazzi, G., Nobili, F., Sixel-Doering, F., Dusek, P., Bes, F., Cortelli, P., Ehgoetz Martens, K., Gagnon, J.F., Gaig, C., Zucconi, M., Trenkwalder, C., Gan-Or, Z., Lo, C., Rolinski, M., Mahlknecht, P., Holzknecht, E., Boeve, A.R., Teigen, L.N., Toscano, G., Mayer, G., Morbelli, S., Dawson, B. and Pelletier, A. (2019) Risk and Pre-dictors of Dementia and Parkinsonism in Idiopathic REM Sleep Behaviour Disorder: A Multicentre Study. Brain, 142, 744-759. https://doi.org/10.1093/brain/awz030 |
