Dual Choice For Dual Target Anti-hiv Therapy - Dual Choice For Dual Target Anti-hiv Therapy - Open Access Pub

DOI10.14302/issn.2324-7339.jcrhap-12-edt.1.1 The approval of raltegravir (Isentress？, Merck & Co.) in 2007 by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS provided novel therapeutic options for patients failing existing therapies. The use of this first HIV integrase inhibitor (INI) in the clinic had a major impact on the outcome of the disease. The antiretroviral therapeutic arsenal is now complete to target the three retroviral enzymes, reverse transcriptase (RT), protease and integrase (IN). Raltegravir is usually administered at 400 mg twice daily in combination with nucleoside reverse transcriptase inhibitors (NRTIs) and offers an excellent efficacy and safety profile1. Nevertheless, some patients fail raltegravir treatment due to the appearance of resistance mutations in the IN gene. There are 3 major pathways involved in raltegravir resistance characterized by the mutation of the IN residues G140/Q148 (double mutation), N155 and Y1432. Novel INIs, which could alleviate partially or completely raltegravir resistance are currently being developed. At the same time, antiviral regimens are being simplified with single oral formulations administered once daily to increase patient treatment adherence. Recently the FDA approved the elvitegravir quad pill (Stribild？, Gilead Sciences) for the treatment of HIV/AIDS (August 27, 2012). This “4 in 1” tablet consists of a combination of elvitegravir, an INI boosted by the pharmaco-enhancer cobicistat and associated with the two NRTIs emtricitabine and tenofovir disoproxil fumarate. Cobicistat, by boosting the elvitegravir blood concentration, allows the administration of elvitegravir at 150 mg once daily with an efficacy and safety comparable to raltegravir 400 mg twice daily3. The elvitegravir quad pill therefore represents the first once daily dual target (IN and RT) anti-HIV tablet available for the treatment of HIV/AIDS4. Elvitegravir and raltegravir share the same mechanism of action but elvitegravir, in contrast to raltegravir, does not interact with the Y143 integrase residue5. Elvitegravir therefore overcomes raltegravir resistance involving the 143 pathway6. The partial alleviation of raltegravir resistance by elvitegravir represents a significant improvement especially in the treatment of patients failing raltegravir therapy due to resistance mutations at the 143 position. This new once daily single formulation regimen should also greatly simplify drug administration and therefore promote patient treatment adherence. A second once daily single formulation tablet referred to as