Pleomorphic Adenoma of the Nasal Septum - Pleomorphic Adenoma of the Nasal Septum - Open Access Pub

Pleomorphic adenomas are uncommon tumors of the nasal cavity. They arise from minor salivary glands, and usually originate from the nasal septum. The tumors are more common in middle-aged females. We present a series of 8 cases of intranasal pleomorphic adenomas. Seven of these tumors originated from the nasal septum, and only one of them originated from the lateral nasal wall. Histopathologic examination of the tumors showed that these tumors have higher epithelial and lower stromal components compared to pleomorphic adenomas of major salivary glands. Endoscopic resection was performed in all cases and the patients were followed up for one year. No recurrences or complications were observed in this series. Endoscopic resection is recommended as the treatment of choice because of its proven efficacy and low morbidity. DOI10.14302/issn.2379-8572.joa-14-561 Salivary gland neoplasms are uncommon and make up less than 5% of all head and neck neoplasms. Pleomorphic adenoma is the most common benign salivary gland tumor. Parotid gland tumors constitute 60% of all pleomorphic adenomas, while minor salivary glands constitute only 8% of them1. Pleomorphic adenomas of minor salivary glands may develop in any site where the minor salivary glands exist2. Rare cases have been reported in the nasal cavity, nasopharynx, oropharynx, and larynx. Intranasal pleomorphic adenomas are rare, slow growing tumors3. These tumors are frequently misdiagnosed because they are usually highly cellular and have few myxoid stroma,,4,5,6In this paper, we present a case series of pleomorphic adenomas of the nasal cavity and discuss the literature on this uncommon tumor. In addition, we discuss relevant issues about the pathology, diagnosis, and management of the tumor. The study included 8 patients (5 females and 3 males) with the diagnosis of nasal pleomorphic adenoma during the period from January 2003 to December 2012. Endoscopic examination was done, and radiological studies included computed tomography (MDCT) with ultra-thin 1mm cuts and multiplanar reconstruction, and magnetic resonance imaging (MRI). Complete endoscopic excision of the mass, including the surrounding mucosa / mucoperichondrium, was performed in all cases. The patients were followed up weekly for the first month and then every 2 weeks until complete healing has occurred. Complete healing usually took place after 8 - 12 weeks. All cases were then re-examined one year postoperatively. Informed consents from all the patients was taken prior to surgery after they were fully informed about the details of the surgical