Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study - Fertility and Sterility

To study the association between maternal diabetes and timing of pubertal development in daughters and sons. Prospective cohort study. Not applicable. A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development. None. Adjusted mean monthly difference in age at attaining pubertal milestones in children born of mothers with diabetes compared with children born of mothers without diabetes. A total of 502 children were born of mothers with diabetes during pregnancy. In daughters exposed to gestational diabetes mellitus, we observed advanced onset in all pubertal milestones. The associations were statistically significant with regard to pubic hair Tanner stage 2 (？4.8 months) (95% confidence interval [CI] ？7.7, ？2.0), pubic hair Tanner stage 3 (？2.2 months) (95 % CI ？4.4, 0.0), pubic hair Tanner stage 5 (？6.0 months) (95% CI ？10.8, ？1.2), and menarche (？2.5 months) (95 % CI ？4.9, 0.0). We observed no tendencies between maternal type 1 or type 2 diabetes mellitus and pubertal development in daughters. We observed no associations between maternal diabetes and pubertal development in sons. Our findings suggest that gestational diabetes mellitus may accelerate the pubertal development in daughters. Our results did not support an association between type 1 or type 2 diabetes mellitus and daughters' pubertal development, as well as between any type of maternal diabetes and sons’ pubertal development. Diabetes mellitus materna y momento de aparición del desarrollo puberal en hijas e hijos: estudio de cohortes nacional Estudiar la asociación entre la diabetes materna y el momento de aparición del desarrollo puberal en hijas e hijos. Estudio prospectivo de cohortes No aplica El estudio incluyó un total de 15,822 de parejas de madre-hijo(a) del Registro Nacional de Nacimientos Danés (Danish National Birth Cohort) y el Registro Puberal (Puberty Cohort). Los datos en el registro sobre diabetes mellitus en la madre, así como el desarrollo puberal de sus hijos, se obtuvieron de manera prospectiva y fueron reportados por la propia población de estudio. Ninguna Diferencia mensual media ajustada por la edad en la que se alcanzan los hitos puberales en ni？os nacidos de madres con diabetes comparados con ni？os nacidos de madres sin diabetes. Un total de 502 ni？os nacieron de madres que tuvieron diabetes durante el embarazo. En hijas expuestas a madres con diabetes mellitus gestacional