Gastric Eosinophilic Granuloma with Total Gastrectomy: A Case Report | Insight Medical Publishing

Introduction: The pathologic feature of gastric eosinophilic granuloma is eosinophil cells infiltrated into the muscular and submucous layer of the stomach. We reported a rare case of eosinophilic granuloma of mimicking gastric cancer. Case report: A-48-year old man was referred to the department of surgical oncology with epigastric discomfort, vomiting and general fatigue for five years. Gastrofiberscope showed an ulcer lesion in the middle and posterior wall of the gastric body, and a circumferential ulcer lesion of the antrum, the lumen was narrowed, and the mirror could not pass. Pathology report of the section was in favor of infiltration with abundant eosinophils and intestinal metaplasia. Permanent pathology was confirmed with immunohistochemical staining, which demonstrated immune-reactivity for vimentin. In consideration of pyloric obstruction and multiple ulcers, an operation scheme of total gastrectomy was formulated by multiple disciplinary team. Postoperative immunohistochemical staining demonstrated immune-reactivity for vimentin and S-100, which established the final diagnosis for GEG. Discussion and Conclusion: A rare case of gastric eosinophilic granumola with three focus distributed at gastric fundus, body and antrum was described. Total gastrectomy was chosen due to three focus and the prognosis was favorable.