Pregnancy, Diabetes Insipidus and Adrenal Insufficiency after Surgical Treatment in Clinically Non-functioning Pituitary Adenoma: A Case Report | Insight Medical Publishing

We report a case of successful pregnancy despite the development of central Diabetes Insipidus (DI) and adrenal insufficiency after surgical treatment of a clinically Non- Functioning Pituitary Adenoma (NFPA). A 36-year-old female who underwent pituitary surgery to treat a clinically NFPA, presented features of central DI and adrenal insufficiency both treated and compensated, and successfully became pregnant. The presence of both conditions in women who previously underwent pituitary surgery to treat NFPA and who became pregnant without intercurrences for either mother and the fetus is unusual. Additionally, in the present case, there was no need for adjustments in the pharmacological therapy. The advent of central DI or adrenal insufficiency after transsphenoidal surgery are frequent complications reported as independent isolated phenomena during the immediate postoperative period or in the context of hypopituitarism. However, the presence of both conditions in women who previously underwent pituitary surgery to treat clinically NFPA and who became pregnant without intercurrences for either mother and the fetus is unusual, which prompted this case report.