Practical Methods for Integrating Genetic Testing Into Clinical Practice for Advanced Prostate Cancer

Over the past several years, it has become abundantly clear that molecular events not only can be defined in prostate cancer but also can affect the treatment of patients and can have important implications for family members. A substantial proportion of aggressive prostate cancers (approximately 25%) have characteristic DNA repair alterations that suggest precision therapy opportunities; approximately 10% have alterations found in the germline and potentially represent inherited cancer predisposition. These findings have led to rapid and far-reaching changes to the field that include exciting new precision treatment opportunities and increased responsibility and challenges surrounding tumor genomic profiling and genetic counseling around inherited cancer risk. GENOMICS VERSUS GENETICS AND IMPLICATIONS FOR PROSTATE CANCER CARE Section: ChooseTop of pageAbstractGENOMICS VERSUS GENETICS ... <