In Vivo Analysis of a Gain-of-Function Mutation Confirms Unc18/Munc18's Role in Priming

Neurotransmitter release at synapses is mediated by the fusion of synaptic vesicles with the plasma membrane. Fusion is mediated by the interaction of three SNARE proteins (soluble NSF-attachment receptor): synaptobrevin in the vesicle membrane and syntaxin and SNAP-25 in the plasma membrane (