Protective Role of Bone Marrow Derived Mesenchymal Stem Cells-Conditioned Medium in the Infarcted Myocardium SciDoc Publishers | Open Access | Science Journals | Media Partners

This study examines the protective effects of mesenchymal stem cell-conditioned (CM) medium on heart tissue after induced myocardial infarction (MI). New Zealand White Rabbits were divided: MI, mesenchymal stem cells (MSC) (300 μl), CM(300 μl) and Control. Echocardiography was applied, and the levels ofIL-6, TGF-β and TNF-α were analyzed using ELISA. All tests were done 1, 4 and 8 weeks after the surgery. Histological studies were done 8 weeks after surgery. CM group showed a significant improvement in cardiac function. The level of IL-6 increased significantly in all weeks after surgery in CM. While the level of TNF-α increased remarkebly in CM group in 4th week. TGF-β decreased significantly in CM group at all the times. Histological findings confirmed the tissue protection effect of CM. In conclusion, our results support the protective role of CM through its paracrine effects on the MI-induced heart