Store-Operated Calcium Channel And Cancer

Advances in approaches and techniques have made it possible for scientists to regulate STIM1-Orai1 communication signaling pathways. There is now a growing body of literature supporting important roles of STIM1 and Orai1 in the invasion and metastasis of various tumors. Although the molecular mechanisms by which hyperactive SOC channel promote cancer metastasis is still not fully understood, several pathways including small GTPase Rac and Ras mediated focal adhesion turnover, adhesion regulated tyrosine kinase Pyk2 and mitogen-activated protein kinases have been implicated in mediating signal transductions downstream of SOC channel. We may look forward in the future to having more information on the role of store-operated calcium channels in tumor progression as well as in the cancer therapy