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- 2018
A case of Wolfram syndrome with chronic renal failureDOI: 10.6065/apem.2018.23.3.166 Abstract: Wolfram syndrome, rare neurodegenerative disorder, is known to be DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) [1,2]. Majority of patients with Wolfram syndrome have mutations of the WFS1 (wolframin) on chromosome 4 [1,2]. Wolfram syndrome is also characterized with gastrointestinal autonomic neuropathy, cardiovascular disorders, hypergonadotrophic hypogonadism in males, neurologic and psychiatric disorders, urinary bladder dysfunction, and diabetic microvascular disorders [1,2]. There are rare case reports of Wolfram syndrome with chronic renal failure in the literature
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