Lost in Translation: Diagnosis Records Show More Inaccuracies After Biopsy in Oncology Care EHRs

The use of diagnosis (DX) data is crucial to secondary use of electronic health record (EHR) data, yet accessible structured DX data often lack in accuracy. DX descriptions associated with structured DX codes vary even after recording biopsy results; this may indicate poor data quality. We hypothesized that biopsy reports in cancer care charts do not improve intrinsic DX data quality. We analyzed DX data for a manually well-annotated cohort of patients with brain neoplasms. We built statistical models to predict the number of fully-accurate (i.e., correct neoplasm type and anatomical location) and inaccurate DX (i.e. type or location contradicts cohort data) descriptions. We found some evidence of statistically larger numbers of fully-accurate (RR=3.07, p=0.030) but stronger evidence of much larger numbers of inaccurate DX (RR=12.3, p=0.001 and RR=19.6, p<0.0001) after biopsy result recording. Still, 65.9% of all DX records were neither fully-accurate nor fully-inaccurate. These results suggest EHRs must be modified to support more reliable DX data recording and secondary use of EHR data