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- 2019
The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's diseaseDOI: 10.1016/j.trci.2019.04.004 Keywords: Clinical trial simulations, Alzheimer's disease, Cox proportional hazards model, Longitudinal data, Mixed model of repeated measures (MMRM), Statistical power, Common close design, Bayesian joint mixed-effect model Abstract: Clinical trials on preclinical Alzheimer’s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression
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