Assessment of the Dissociation Energetics of Some Selected Ligand Drugs Bound on Human Serum Albumin by Differential Scanning Calorimetry

DSC thermograms of heat-induced denaturation of stabilizers removed HSA incubated with diazepam (I) diazepam in excess (II), and ibuprofen (III) at concentration levels of a 0.00125, b 0.0025, and c 0.005, d 0.01, e 0.04, and f 0.08 mmole/g-protein for diazepam and g 0.0047, h 0.0082, and i 0.0093 mmole/g-protein for ibuprofen, respectivel