Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma

Purpose: In this investigation, a new version of magnetic solid phase extraction (MSPE) performed in a narrow–bore tube has been proposed. In this study, hydrophobic octyl (C8) functionalized Fe3O4 magnetic nanoparticles (MNPs) stabilized by SiOH groups (Fe3O4@SiO2@C8) are used as magnetic nano–sorbents for the extraction of cardiovascular drugs from human plasma prior to their determination by high performance liquid chromatography–photodiode array detection