Germ Cell Tumors: Updates on Epidemiology, Biology, and Treatment Considerations

Germ cell tumors (GCTs) are the most common solid tumors in young men. GCTs represent a rare oncologic success story with 5-year cure rates exceeding 98% for early-stage tumors and 80% for patients with metastatic disease, attributable to the integration of surgery, cisplatin-based chemotherapy, and radiation therapy. Despite the excellent clinical outcomes in testicular GCTs, significant challenges and opportunities exist, as GCTs represent the most life years lost for nonpediatric malignancies [1]