Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer

Redox homeostasis and the role of NADPH. NADPH, nicotinamide adenine dinucleotide phosphate; NADP+, triphosphopyridine nucleotide; G-6-PD, glucose-6-phosphate dehydrogenase; MTHFD 1/2, methylenetetrahydrofolate dehydrogenase 1/2; GSH, reduced glutathione; GSSG, oxidized glutathione; ROS, reactive oxygen specie