Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives

Origin of DCs. MDPs among hematopoietic stem cells give rise to common FLT3-expressing CMPs, which are the precursors of pre-cDCs and pDCs. Monocytes can differentiate into MODCs under the appropriate circumstances and Pre-cDCs circulate into lung tissue and differentiate into different classes of DCs. MDP: Monocyte-DC progenitors; FLT3: colony stimulating factor 1 receptor (FMS)-like tyrosine kinase 3; pDC: plasmacytoid DC; cDC: conventional DC; MODCs: monocyte-derived DCs: CMPs: common myeloid progenitor