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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

The impact of incorrectly recorded parentage on inferred genotypes over multiple generations

DOI: 10.1186/s40575-019-0074-3

Keywords: Disease mutations, Genetic testing, Disease carriers, Hereditary clear status

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Abstract:

Diagrammatic representation of the iterative calculation of genotype probabilities of progeny over successive generations of individuals assigned ‘hereditary clear’ (HC) status. The actual sire genotype probabilities are the genotype frequencies in the background population assumed in HWE, occurring at a constant false paternity rate of 5%. The initial dam and nominated sire genotype probabilities are from individuals with genotypes known from testing, so P (AA)?=?1. Thereafter over successive generations, the calculated genotype probabilities of progeny (assigned HC status) in generation n become the parent genotype probabilities in generation n?+?

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