OMICs approaches-assisted identification of macrophages-derived MIP-1γ as the therapeutic target of botanical products TNTL in diabetic retinopathy

High doses of TNTL possessed hypoglycemic effects. a. showed that TNTL treatment did not significantly change the body weight of hyperglycemic mice; b. showed that TNTL dose-dependently suppressed the increase of random blood glucose (RBG) by week; c. showed that TNTL dose-dependently reduced fasting blood glucose (FBG) after 4-week treatment; d. showed that medium and high doses of TNTL improved the glucose tolerance in hyperglycemic mice; e. showed that TNTL at medium and high doses can significantly reduce serum HbA1c levels. *p？<？0.05, **p？<？0.01, ***p？<？0.001 when compared with model grou