BOK promotes chemical-induced hepatocarcinogenesis in mice

BOK contributes to DEN-induced liver damage. a Bok mRNA expression in the livers of WT and Bok -/- animals after DEN exposure. Hprt served as reference gene. Values represent the mean？±？SD (n？=？3 mice per group). b Serum ALT levels were determined in WT and Bok -/- mice after DEN exposure (100？mg/kg BW). Values represent mean？±？SD. c Representative fluorescence micrographs of TUNEL staining and d quantification of TUNEL-positive cells in livers from WT and Bok -/- animals treated with DEN (100？mg/kg BW). Values represent the mean？±？SD (n？=？3 mice per group). e Quantitative western blot analysis using near-infrared fluorescence of activated caspase-3 in liver lysates from WT and Bok -/- animals 3 days after DEN (100？mg/kg) injection. Values represent the mean？±？SD (n？=？3 mice per group