Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity

Exercise promoted FNDC5/irisin formation and signaling. FNDC5/irisin has been shown to affect signaling of osteocytes and adipocytes through the pathways shown on the left and macrophages, endothelial cells, neurons, and cardiomyocytes through the pathways shown on the righ