Function and dysfunction of plasma cells in intestine

This manuscript has the following components. First, after describing the origin of plasma cells (PCs), it summarizes their general biological features and common functions. The second component reveals the characteristics of short-lived PCs (SLPCs) and long-lived PCs (LLPCs). Notably, we depict how LLPCs survive in bone marrow and why they could be a double-edged sword in the human body. Thirdly, we summarize the functions of PCs, especially their function in the intestine. Next, we address some relationship between PC disfunction and intestinal diseases. Last but not least, some novel viewpoints on the pathogenesis of inflammatory bowel disease (IBD) and the unique role of IgA in intestinal food allergies and tumors are also emphasized