Biological Monitoring of 4 Antineoplastic Drugs in Health Care Workers from 2 Adult Hospitals: A Pilot Study

Up to 75 000 Canadian workers are exposed to antineoplastic drugs, especially pharmacists, pharmacy technicians, and nurses.1 Adverse effects include risk of genotoxicity (evidenced by increases in genotoxicity biomarkers), reproductive risks (congenital malformations, miscarriages), and cancers.2,3 Canadian and US guidelines recommend environmental monitoring.4–7 Biological monitoring is mainly used in research settings, but could also help to confirm whether workers are free of contamination