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- 2016
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsDOI: 10.1186/s13008-016-0020-7 Keywords: Cullin-2, Elongin, E3 ubiquitin ligase, VHL, Hypoxia inducible factor, Rack1, E4orf6, Viral host defense Abstract: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases
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