Antitumor Effect of 131I-Labeled Anti-VEGFR2 Targeted Mesoporous Silica Nanoparticles in Anaplastic Thyroid Cancer

The characteristics of nanoparticles. Characterizations of MSNs (a), BSA-MSNs (b), BSA-MSNs-anti-VEGFR2 (c), and nitrogen adsorption-desorption isotherm and Barrett–Joyner–Halenda (BJH) pore size distribution curves of MSNs (d). The transmission electron microscopy images show that all had regular (uniform spherical) morphology. The dynamic light scattering images show that all were uniform, with average sizes of 108 nm, 139 nm, and 163 nm, respectively. BET and BJH analyses demonstrated typical type-IV isotherms, consistent with a mesoporous structur