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- 2018
Activation of WEE1 confers resistance to PI3K inhibition in glioblastomaKeywords: mitotic catastrophic cell death, PI3K inhibition resistance, WEE1 Abstract: Oncogenic activation of phosphatidylinositol-3 kinase (PI3K) signaling plays a pivotal role in the development of glioblastoma (GBM). However, pharmacological inhibition of PI3K has so far not been therapeutically successful due to adaptive resistance through a rapid rewiring of cancer cell signaling. Here we identified that WEE1 is activated after transient exposure to PI3K inhibition and confers resistance to PI3K inhibition in GBM
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