Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body

Determination of optimal particle number per dwell time for accurate sp-ICP-MS analysis. A series of nAg solutions (600？fg/mL to 2,500？pg/mL) were analyzed by sp-ICP-MS. a To determine the relationship between the concentration of nAg100 and the number of detected particles, a curve for the detected particles (solid line) the theoretical values (dotted line) were plotted. b The number of detected particles subtracted from the theoretical value was plotted in the vertical axis to determine the optimal particle number. Each point is the result of a single trial (n =？1