AKT1low quiescent cancer cells in ductal carcinoma in situ of the breast

AKT1low QCCs are found within DCIS. a Hematoxylin and eosin stained section showing a representative area of ductal carcinoma in situ; b Multiplex immunofluorescence of DCIS tissue shown in a with AKT1low QCC cluster marked by a white arrow and the marker profile: AKTlow (green), H3K9me2low (yellow) and HES1high (red); inset image is enlarged to show QCC marker detail. c Digital tumor map of DCIS tissue shown in a and b with AKT1low QCCs shown in red and proliferating cancer cells in blue. Images were taken at ×2