A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel

Histology. a Representative portal tract from the liver biopsy with absence of the interlobular bile duct. The hepatocytes show severe small droplet steatosis. (H&E, ×400). b The explant liver showed a biliary pattern of cirrhosis with extensive ductular reaction (H&E, ×40). c A portal tract from the liver explant with absence of the interlobular bile duct and associated ductular reaction and cholestasis (H&E, ×20). d Example of normal portal trac