Pan-cancer analysis connects tumor matrisome to immune response

Common matrisome variation in human cancers. a Schematic of the study design: 11 cancer type-specific, merged microarray-acquired dataset (MMD) were newly generated for parallel analyses with TCGA cohorts. b Circular plot illustrating the ranked position of matrisome genes based on differential expression (cancer vs. normal) in TCGA cohorts. 1 denotes the most differentially expressed gene (DEG). Black and gray lines represent the ranked position of generic and lung-specific TMI signature, respectively. c TMI in tumor vs. non-tumor tissues across 11 cancer types. The black horizontal line indicates the mean of the samples. ***Mann–Whitney U-test P？<？0.001, **P？<？0.01, *P？<？0.05. d Area under the ROC curves (AUCs) of the TMI classifier for all cancer types. Smooth ROC curves are drawn for MMDs (left) and TCGA cohorts (right