Emerging role of precision medicine in biliary tract cancers

Emerging role of precision medicine in biliary tract cancers. Yellow boxes highlight US FDA-approved drugs and drugs undergoing clinical investigation as reviewed, with arrows indicating pathway/target activation and blocked lines indicating pathway/target inhibition. BTC targets/pathways discussed are shown in color-coded boxes according to subcellular localization, blue？=？cell surface, orange？=？cytsolic, red？=？mitochondrial, and green？=？nuclear. “↑” denotes over-expression, “Δ” denotes copy number abbreation and/or point mutation, a lighting bolt symbol denotes a synthetic lethal interaction between drug(s) and target(s) liste