Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice

CXCR3 is not required in models of acute itch in the neck and cheek. A Acute itch induced by intradermal injection of compound 48/80 (48/80, 100 μg) or chloroquine (CQ, 200 μg) into the neck skin was comparable in WT and Cxcr3 ？/？ mice. B, C Acute itch and pain, which were induced by intradermal injection of 48/80 (B) or CQ (C) into the cheek, induced similar wipes and scratches in WT and Cxcr3 ？/？ mice