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-  2018 

Combining Human and Rodent Genetics to Identify New Analgesics

DOI: 10.1007/s12264-017-0152-z

Keywords: Chronic pain, Genetics, Mouse models, Tetrahydrobiopterin, Sepiapterin reductase, Analgesics

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Abstract:

Reverse-engineering a relevant pathway from pain patients into rodents and back to patients. A complex interplay needs to be established between the patient and the experimental animal in order to achieve rational therapy design most efficiently

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