Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone

Adult Sdy mice given postnatal polyI:C displayed schizophrenia relevant behavioural abnormalities. a Experimental design in which mice were injected at postnatal day 5 (P5) to P9, and characterized in adulthood. b Spontaneous locomotor activity at P70. c Mean startle amplitude (baseline level) to an acoustic pulse of 120 decibels in ten trials without any prepulses. d, e Percent of prepulse inhibition (PPI) to a main pulse of 120 decibels following prepulse (PP) intensities of 3, 6, 9, 12 or 15 decibels (5 trials per each PP). f Novel object recognition in adulthood. g Exploration times. All values are mean？±？s.e.m. of N？=？12–17 per group for (b) and N？=？12 per group for c–g. Data were analyzed using two-way ANOVA for (c, g) with Tukey’s post hoc test for (b, e) or Student’s two-tailed t-test for (f). *P？<？0.05 and **P？<？0.0